The Apnea Positive Pressure Long-term Efficacy Study (APPLES): Rationale, design, methods, and procedures

Clete A. Kushida, Deborah A. Nichols, Stuart F. Quan, James L. Goodwin, David P. White, Daniel J. Gottlieb, James K. Walsh, Paula K. Schweitzer, Christian Guilleminault, Richard D. Simon, Eileen B. Leary, Pamela R. Hyde, Tyson H. Holmes, Daniel A. Bloch, Sylvan Green, Linda K. McEvoy, Alan Gevins, William C. Dement

    Research output: Contribution to journalArticlepeer-review

    56 Scopus citations

    Abstract

    Study Objective: To assess the size, time course, and durability of the effects of long-term continuous positive airway pressure (CPAP) therapy on neurocognitive function, mood, sleepiness, and quality of life in patients with obstructive sleep apnea. Design: Randomized, double-blinded, 2-arm, sham-controlled, multicenter, long-term, intention-to-treat trial of CPAP therapy. Setting: Sleep clinics and laboratories at 5 university medical centers and community-based hospitals. Patients or Participants: Target enrollment is 1100 randomly assigned subjects across 5 clinical centers. Interventions: Active versus sham (subtherapeutic) CPAP. Measurements and Results: A battery of conventional and novel tests designed to evaluate neurocognitive function, mood, sleepiness, and quality of life. Conclusions: The Apnea Positive Pressure Long-term Efficacy Study (APPLES) is designed to study obstructive sleep apnea and test the effects of CPAP through a comprehensive, controlled, and long-term trial in a large sample of subjects with obstructive sleep apnea.

    Original languageEnglish (US)
    Pages (from-to)288-300
    Number of pages13
    JournalJournal of Clinical Sleep Medicine
    Volume2
    Issue number3
    DOIs
    StatePublished - Jul 15 2006

    Keywords

    • APPLES
    • Continuous positive airway pressure
    • Neurocognitive function
    • Obstructive sleep apnea

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine
    • Neurology
    • Clinical Neurology

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