Abstract
Study Objective: To assess the size, time course, and durability of the effects of long-term continuous positive airway pressure (CPAP) therapy on neurocognitive function, mood, sleepiness, and quality of life in patients with obstructive sleep apnea. Design: Randomized, double-blinded, 2-arm, sham-controlled, multicenter, long-term, intention-to-treat trial of CPAP therapy. Setting: Sleep clinics and laboratories at 5 university medical centers and community-based hospitals. Patients or Participants: Target enrollment is 1100 randomly assigned subjects across 5 clinical centers. Interventions: Active versus sham (subtherapeutic) CPAP. Measurements and Results: A battery of conventional and novel tests designed to evaluate neurocognitive function, mood, sleepiness, and quality of life. Conclusions: The Apnea Positive Pressure Long-term Efficacy Study (APPLES) is designed to study obstructive sleep apnea and test the effects of CPAP through a comprehensive, controlled, and long-term trial in a large sample of subjects with obstructive sleep apnea.
Original language | English (US) |
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Pages (from-to) | 288-300 |
Number of pages | 13 |
Journal | Journal of Clinical Sleep Medicine |
Volume | 2 |
Issue number | 3 |
DOIs | |
State | Published - Jul 15 2006 |
Externally published | Yes |
Keywords
- APPLES
- Continuous positive airway pressure
- Neurocognitive function
- Obstructive sleep apnea
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Neurology
- Clinical Neurology