The Ageing Hippocampus

Lan T. Hoang, James P. Lister, Carol A. Barnes

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


This chapter reviews alterations observed in the hippocampus during normative ageing in the absence of pathology. Topics include discussions of age-related spatial memory deficits across mammalian species, as well as neuroanatomical, biophysical, and electrophysiological changes observed in the aged hippocampus. Further, the impact that these changes might have on plasticity mechanisms and dynamic processes such as gene expression and epigenetic modifications over the lifespan is discussed. Special emphasis is given to the fact that normative ageing is distinct from neuropathological states such as Alzheimer's disease. Moreover, this overview highlights how the study of normal ageing in the hippocampus has furthered the understanding of the specificity of pathological processes as well as presented possible avenues for the development of interventions, treatments, or therapeutic strategies for optimizing cognition during the normal life course.

Original languageEnglish (US)
Title of host publicationThe Clinical Neurobiology of the Hippocampus
Subtitle of host publicationAn Integrative view
PublisherOxford University Press
ISBN (Electronic)9780199949922
ISBN (Print)9780199592388
StatePublished - Sep 20 2012


  • DNA methylation
  • Electrophysiology
  • Immediate-early genes
  • Multiple single-unit recording
  • Neuroanatomical changes
  • Place cells
  • Plasticity
  • Spatial memory

ASJC Scopus subject areas

  • General Neuroscience


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