The actions of melanin-concentrating hormone (MCH) on passive avoidance in rats: A preliminary study

Rosanne B. McBride; Bill E. Beckwith; Robyn R. Swenson; Tomi K. Sawyer; Mac E. Hadley; Terry O. Matsunaga; Victor J. Hruby

doi:10.1016/0196-9781(94)90105-8

The actions of melanin-concentrating hormone (MCH) on passive avoidance in rats: A preliminary study

Rosanne B. McBride, Bill E. Beckwith, Robyn R. Swenson, Tomi K. Sawyer, Mac E. Hadley, Terry O. Matsunaga, Victor J. Hruby

Medical Imaging

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Melanin-concentrating hormone (MCH) is a hepadecapeptide hormone that is synthesized in the CNS and is responsible for melanosome aggregation in the teleost fish. Recent evidence suggests that this peptide hormone has a unique distribution in the mammalian brain, which leads to the speculation that it may serve as a neuromodulator. The present study was undertaken to explore the comparative effects of MCH to those of α-melanocyte-stimulating Hormone (MSH) (a neuropeptide that is known to influence learning) on the rate of extinction of a passive avoidance response in rats. Both MCH and MSH were administered SC at 10 μg per animal. Treatment with MCH appeared to hasten, whereas treatment with MSH appeared to delay, extinction of the passive avoidance response.

Original language	English (US)
Pages (from-to)	757-759
Number of pages	3
Journal	Peptides
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/0196-9781(94)90105-8
State	Published - 1994

Keywords

Behavior
Extinction
Learning
MCH
MSH
Memory
Neuropeptides
Passive avoidance

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(94)90105-8

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title = "The actions of melanin-concentrating hormone (MCH) on passive avoidance in rats: A preliminary study",

abstract = "Melanin-concentrating hormone (MCH) is a hepadecapeptide hormone that is synthesized in the CNS and is responsible for melanosome aggregation in the teleost fish. Recent evidence suggests that this peptide hormone has a unique distribution in the mammalian brain, which leads to the speculation that it may serve as a neuromodulator. The present study was undertaken to explore the comparative effects of MCH to those of α-melanocyte-stimulating Hormone (MSH) (a neuropeptide that is known to influence learning) on the rate of extinction of a passive avoidance response in rats. Both MCH and MSH were administered SC at 10 μg per animal. Treatment with MCH appeared to hasten, whereas treatment with MSH appeared to delay, extinction of the passive avoidance response.",

keywords = "Behavior, Extinction, Learning, MCH, MSH, Memory, Neuropeptides, Passive avoidance",

author = "McBride, {Rosanne B.} and Beckwith, {Bill E.} and Swenson, {Robyn R.} and Sawyer, {Tomi K.} and Hadley, {Mac E.} and Matsunaga, {Terry O.} and Hruby, {Victor J.}",

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AU - McBride, Rosanne B.

AU - Beckwith, Bill E.

AU - Swenson, Robyn R.

AU - Sawyer, Tomi K.

AU - Hadley, Mac E.

AU - Matsunaga, Terry O.

AU - Hruby, Victor J.

PY - 1994

Y1 - 1994

N2 - Melanin-concentrating hormone (MCH) is a hepadecapeptide hormone that is synthesized in the CNS and is responsible for melanosome aggregation in the teleost fish. Recent evidence suggests that this peptide hormone has a unique distribution in the mammalian brain, which leads to the speculation that it may serve as a neuromodulator. The present study was undertaken to explore the comparative effects of MCH to those of α-melanocyte-stimulating Hormone (MSH) (a neuropeptide that is known to influence learning) on the rate of extinction of a passive avoidance response in rats. Both MCH and MSH were administered SC at 10 μg per animal. Treatment with MCH appeared to hasten, whereas treatment with MSH appeared to delay, extinction of the passive avoidance response.

AB - Melanin-concentrating hormone (MCH) is a hepadecapeptide hormone that is synthesized in the CNS and is responsible for melanosome aggregation in the teleost fish. Recent evidence suggests that this peptide hormone has a unique distribution in the mammalian brain, which leads to the speculation that it may serve as a neuromodulator. The present study was undertaken to explore the comparative effects of MCH to those of α-melanocyte-stimulating Hormone (MSH) (a neuropeptide that is known to influence learning) on the rate of extinction of a passive avoidance response in rats. Both MCH and MSH were administered SC at 10 μg per animal. Treatment with MCH appeared to hasten, whereas treatment with MSH appeared to delay, extinction of the passive avoidance response.

KW - Behavior

KW - Extinction

KW - Learning

KW - MCH

KW - MSH

KW - Memory

KW - Neuropeptides

KW - Passive avoidance

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JO - Peptides

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ER -

The actions of melanin-concentrating hormone (MCH) on passive avoidance in rats: A preliminary study

Abstract

Keywords

ASJC Scopus subject areas

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