TGF-ß1 accelerates bone growth into porous TCP-coated PBT scaffolds

J. A. Szivek, B. K. Garrison, E. Nelson, D. Margolis, D. W. DeYoung, R. K. Vaidyanathan

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Currently, total joint replacements are used to relieve pain and restore motion to arthritic joints. The drawbacks include loss of bone stock and proprioception. Implantable cartilage covered scaffolds would be an alternative, requiring that cartilage cells be collected from patients and grown into tissue on the scaffold. Rapid bone ingrowth to anchor scaffolds will be essential for good cartilage integration. The purpose of this study was to evaluate bone ingrowth into tricalcium phosphate (TCP) coated polybutylene terephthalate (PBT) scaffolds with and without transforming growth factor ß1 (TGF-ß1). Plain, latexed coated (LC) and vacuum impregnated (VI) PBT scaffolds were studied.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress


OtherTransactions - 7th World Biomaterials Congress

ASJC Scopus subject areas

  • Engineering(all)


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