tetra-O-Methylnordihydroguaiaretic acid inhibits melanoma in vivo

Joshua D. Lambert, Ross O. Meyers, Barbara N. Timmermann, Robert T. Dorr

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


tetra-O-Methylnordihydroguaiaretic acid is a derivative of a naturally-occurring lignan, nordihydroguaiaretic acid, that has previously been shown to inhibit various cancer types in vitro and in vivo. Additionally, nordihydroguaiaretic acid has been shown to have nephrotoxic effects in the rat. Here we show that tetra-O-methylnordihydroguaiaretic acid inhibits the growth of a number of tumor cell lines in vitro by inducing apoptosis in a non-schedule-dependent manner. Further, this compound inhibits the synthesis of DNA by melanoma cells and causes cell cycle arrest in G0/G1 and G2/M phases of the cell cycle. tetra-O-Methylnordihydroguaiaretic acid also inhibits the growth of both murine and human melanomas and human colon cancer in vivo without apparent hepatic or renal toxicity.

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalCancer Letters
Issue number1
StatePublished - Aug 28 2001


  • Colon cancer
  • Melanoma
  • Nordihydroguaiaretic acid
  • tetra-O-Methylnordihydroguaiaretic acid

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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