TY - JOUR
T1 - Terapia cognitiva basada en mindfulness
T2 - eficacia y predictores de respuesta con RM-funcional en pacientes con trastorno obsesivo-compulsivo. Protocolo de estudio para un ensayo clínico aleatorizado
AU - Miquel-Giner, Neus
AU - Vicent-Gil, Muriel
AU - Martínez-Zalacaín, Ignacio
AU - Porta-Casteras, Daniel
AU - Mar, Lorea
AU - López-Solà, Marina
AU - Andrews-Hanna, Jessica R.
AU - Soriano-Mas, Carles
AU - Menchón, José Manuel
AU - Cardoner, Narcís
AU - Alonso, Pino
AU - Serra-Blasco, Maria
AU - López-Solà, Clara
N1 - Funding Information:
This study was supported by Carlos III Health Institute FIS PI18/00856 and FIS PIS 19/01184 and FEDER funds (“A way to build Europe”) and Research and Innovation Taulí Grant Corporacion PT CIR2016/030 .
Publisher Copyright:
© 2022 SEP y SEPB
PY - 2022
Y1 - 2022
N2 - Background: Around 40–50% of patients with obsessive-compulsive disorder (OCD) suffer from obsessions and compulsions after receiving first-line treatments. Mindfulness-based cognitive therapy (MBCT) has been proposed as a reasonable augmentation strategy for OCD. MBCT trains to decentre from distressful thoughts and emotions by focusing on them voluntarily and with consciousness. This practice develops alternative ways to deal with obsessions, which could increase non-reactivity behaviours and, in turn, reduce compulsions. This study aims to investigate the efficacy of MBCT to improve OCD symptoms. Secondly, it pursues to investigate which socio-demographic, clinical, and neurobiological characteristics mediate or moderate the MBCT response; and identify potential biomarkers of positive/negative response. Methods: This study is a randomised clinical trial (RCT) of 60 OCD patients who do not respond to first-line treatments. Participants will be randomised to either an MBCT program or treatment as usual. The MBCT group will undergo 10 weekly sessions of 120 min. Principal outcome: change in OCD severity symptoms using clinician and self-reported measures. Also, participants will undergo a comprehensive evaluation assessing comorbid clinical variables, neuropsychological functioning and thought content. Finally, a comprehensive neuroimaging protocol using structural and functional magnetic resonance imaging will be acquired in a 3T scanner. All data will be obtained at baseline and post-intervention. Discussion: This study will assess the efficacy of mindfulness in OCD patients who do not achieve clinical recovery after usual treatment. It is the first RCT in this subject examining clinical, neuropsychological and neuroimaging variables to examine the neural patterns associated with the MBCT response. Clinical trials registration: NCT03128749.
AB - Background: Around 40–50% of patients with obsessive-compulsive disorder (OCD) suffer from obsessions and compulsions after receiving first-line treatments. Mindfulness-based cognitive therapy (MBCT) has been proposed as a reasonable augmentation strategy for OCD. MBCT trains to decentre from distressful thoughts and emotions by focusing on them voluntarily and with consciousness. This practice develops alternative ways to deal with obsessions, which could increase non-reactivity behaviours and, in turn, reduce compulsions. This study aims to investigate the efficacy of MBCT to improve OCD symptoms. Secondly, it pursues to investigate which socio-demographic, clinical, and neurobiological characteristics mediate or moderate the MBCT response; and identify potential biomarkers of positive/negative response. Methods: This study is a randomised clinical trial (RCT) of 60 OCD patients who do not respond to first-line treatments. Participants will be randomised to either an MBCT program or treatment as usual. The MBCT group will undergo 10 weekly sessions of 120 min. Principal outcome: change in OCD severity symptoms using clinician and self-reported measures. Also, participants will undergo a comprehensive evaluation assessing comorbid clinical variables, neuropsychological functioning and thought content. Finally, a comprehensive neuroimaging protocol using structural and functional magnetic resonance imaging will be acquired in a 3T scanner. All data will be obtained at baseline and post-intervention. Discussion: This study will assess the efficacy of mindfulness in OCD patients who do not achieve clinical recovery after usual treatment. It is the first RCT in this subject examining clinical, neuropsychological and neuroimaging variables to examine the neural patterns associated with the MBCT response. Clinical trials registration: NCT03128749.
KW - MBCT
KW - Neuroimaging
KW - Psychotherapy
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UR - http://www.scopus.com/inward/citedby.url?scp=85143886078&partnerID=8YFLogxK
U2 - 10.1016/j.rpsm.2022.11.002
DO - 10.1016/j.rpsm.2022.11.002
M3 - Article
AN - SCOPUS:85143886078
SN - 1888-9891
JO - Revista de Psiquiatria y Salud Mental
JF - Revista de Psiquiatria y Salud Mental
ER -