Tensins: A New Switch in Cell Migration

Ghassan Mouneimne, Joan S. Brugge

Research output: Contribution to journalShort surveypeer-review

18 Scopus citations


Epidermal Growth Factor (EGF) is an important regulator of normal epithelial and carcinoma cell migration. The mechanism by which EGF induces cell migration is not fully understood. A recent report in Nature Cell Biology (Katz et al., 2007) demonstrates that EGF regulates migration through a switch in the expression of two tensin isoforms, weakening the association of β1 integrin with the actin cytoskeleton in focal adhesions.

Original languageEnglish (US)
Pages (from-to)317-319
Number of pages3
JournalDevelopmental Cell
Issue number3
StatePublished - Sep 4 2007

ASJC Scopus subject areas

  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • Developmental Biology
  • Cell Biology


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