Tensins: A New Switch in Cell Migration

Ghassan Mouneimne; Joan S. Brugge

doi:10.1016/j.devcel.2007.08.010

Tensins: A New Switch in Cell Migration

Ghassan Mouneimne, Joan S. Brugge

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

Epidermal Growth Factor (EGF) is an important regulator of normal epithelial and carcinoma cell migration. The mechanism by which EGF induces cell migration is not fully understood. A recent report in Nature Cell Biology (Katz et al., 2007) demonstrates that EGF regulates migration through a switch in the expression of two tensin isoforms, weakening the association of β1 integrin with the actin cytoskeleton in focal adhesions.

Original language	English (US)
Pages (from-to)	317-319
Number of pages	3
Journal	Developmental Cell
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.devcel.2007.08.010
State	Published - Sep 4 2007

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Developmental Biology
Cell Biology

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10.1016/j.devcel.2007.08.010

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title = "Tensins: A New Switch in Cell Migration",

abstract = "Epidermal Growth Factor (EGF) is an important regulator of normal epithelial and carcinoma cell migration. The mechanism by which EGF induces cell migration is not fully understood. A recent report in Nature Cell Biology (Katz et al., 2007) demonstrates that EGF regulates migration through a switch in the expression of two tensin isoforms, weakening the association of β1 integrin with the actin cytoskeleton in focal adhesions.",

author = "Ghassan Mouneimne and Brugge, {Joan S.}",

year = "2007",

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AU - Brugge, Joan S.

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N2 - Epidermal Growth Factor (EGF) is an important regulator of normal epithelial and carcinoma cell migration. The mechanism by which EGF induces cell migration is not fully understood. A recent report in Nature Cell Biology (Katz et al., 2007) demonstrates that EGF regulates migration through a switch in the expression of two tensin isoforms, weakening the association of β1 integrin with the actin cytoskeleton in focal adhesions.

AB - Epidermal Growth Factor (EGF) is an important regulator of normal epithelial and carcinoma cell migration. The mechanism by which EGF induces cell migration is not fully understood. A recent report in Nature Cell Biology (Katz et al., 2007) demonstrates that EGF regulates migration through a switch in the expression of two tensin isoforms, weakening the association of β1 integrin with the actin cytoskeleton in focal adhesions.

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JO - Developmental Cell

JF - Developmental Cell

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Tensins: A New Switch in Cell Migration

Abstract

ASJC Scopus subject areas

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