Temporal associations of plasma levels of the secreted phospholipase A2 family and mortality in severe COVID-19

Eric Lu, Aki Hara, Shudong Sun, Brian Hallmark, Justin M. Snider, Michael C. Seeds, Joseph C. Watkins, Charles E. McCall, Hao Helen Zhang, Guang Yao, Floyd H. Chilton

Research output: Contribution to journalArticlepeer-review

Abstract

Previous research suggests that group IIA-secreted phospholipase A2 (sPLA2-IIA) plays a role in and predicts lethal COVID-19 disease. The current study reanalyzed a longitudinal proteomic data set to determine the temporal relationship between levels of several members of a family of sPLA2 isoforms and the severity of COVID-19 in 214 ICU patients. The levels of six secreted PLA2 isoforms, sPLA2-IIA, sPLA2-V, sPLA2-X, sPLA2-IB, sPLA2-IIC, and sPLA2-XVI, increased over the first 7 ICU days in those who succumbed to the disease but attenuated over the same time period in survivors. In contrast, a reversed pattern in sPLA2-IID and sPLA2-XIIB levels over 7 days suggests a protective role of these two isoforms. Furthermore, decision tree models demonstrated that sPLA2-IIA outperformed top-ranked cytokines and chemokines as a predictor of patient outcome. Taken together, proteomic analysis revealed temporal sPLA2 patterns that reflect the critical roles of sPLA2 isoforms in severe COVID-19 disease.

Original languageEnglish (US)
JournalEuropean Journal of Immunology
DOIs
StateAccepted/In press - 2024

Keywords

  • COVID-19
  • Proteomics
  • sPLA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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