TY - JOUR
T1 - Telomeres and telomerase in renal health
AU - Wills, Lauren P.
AU - Schnellmann, Rick G.
PY - 2011/1
Y1 - 2011/1
N2 - The role of telomeres and telomerase in human biology has been studied since the early 1990s because telomere attrition is implicated in various diseases including cardiovascular dysfunction, carcinogenesis, and the progression of acute kidney injury. Telomeric length is a reliable indicator of intrinsic biologic age and a surrogate for the mitotic clock. Because the prevalence of chronic kidney disease increases with age, telomere length and telomerase activity may play a role in its progression.
AB - The role of telomeres and telomerase in human biology has been studied since the early 1990s because telomere attrition is implicated in various diseases including cardiovascular dysfunction, carcinogenesis, and the progression of acute kidney injury. Telomeric length is a reliable indicator of intrinsic biologic age and a surrogate for the mitotic clock. Because the prevalence of chronic kidney disease increases with age, telomere length and telomerase activity may play a role in its progression.
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U2 - 10.1681/ASN.2010060662
DO - 10.1681/ASN.2010060662
M3 - Article
C2 - 21209253
AN - SCOPUS:78651393889
SN - 1046-6673
VL - 22
SP - 39
EP - 41
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 1
ER -