Telomere biology of the chicken: A model for aging research

Susan E. Swanberg; Thomas H. O'Hare; Elizabeth A. Robb; Charmaine M. Robinson; Hong Chang; Mary E. Delany

doi:10.1016/j.exger.2010.04.002

Telomere biology of the chicken: A model for aging research

Susan E. Swanberg, Thomas H. O'Hare, Elizabeth A. Robb, Charmaine M. Robinson, Hong Chang, Mary E. Delany

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Division-dependent telomere shortening correlating with age triggers senescence on a cellular level and telomere dysfunction can facilitate oncogenesis. Therefore, the study of telomere biology is critical to the understanding of aging and cancer. The domestic chicken, a classic model for the study of developmental biology, possesses a telomere genome with highly conserved aspects and distinctive features which make it uniquely suited for the study of telomere maintenance mechanisms, their function and dysfunction. The purpose of this review is to highlight the chicken as a model for aging research, specifically as a model for telomere and telomerase research, and to increase its utility as such by describing developments in the study of chicken telomeres and telomerase in the context of related research in human and mouse.

Original language	English (US)
Pages (from-to)	647-654
Number of pages	8
Journal	Experimental Gerontology
Volume	45
Issue number	9
DOIs	https://doi.org/10.1016/j.exger.2010.04.002
State	Published - Sep 2010
Externally published	Yes

Keywords

DF-1
DT40
Mega-telomeres
Reconstitution of telomerase
Splice variants
Telomerase
Telomere
TERT
TR

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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10.1016/j.exger.2010.04.002

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title = "Telomere biology of the chicken: A model for aging research",

abstract = "Division-dependent telomere shortening correlating with age triggers senescence on a cellular level and telomere dysfunction can facilitate oncogenesis. Therefore, the study of telomere biology is critical to the understanding of aging and cancer. The domestic chicken, a classic model for the study of developmental biology, possesses a telomere genome with highly conserved aspects and distinctive features which make it uniquely suited for the study of telomere maintenance mechanisms, their function and dysfunction. The purpose of this review is to highlight the chicken as a model for aging research, specifically as a model for telomere and telomerase research, and to increase its utility as such by describing developments in the study of chicken telomeres and telomerase in the context of related research in human and mouse.",

keywords = "DF-1, DT40, Mega-telomeres, Reconstitution of telomerase, Splice variants, Telomerase, Telomere, TERT, TR",

author = "Swanberg, {Susan E.} and O'Hare, {Thomas H.} and Robb, {Elizabeth A.} and Robinson, {Charmaine M.} and Hong Chang and Delany, {Mary E.}",

note = "Funding Information: Supported by the National Research Initiative Grant no. 2005-35205-16679 from the USDA National Institute of Food and Agriculture (NIFA) Animal Genome program and NIFA Multistate Research Projects NE-1034 (CA-D*-ASC-7281-RR) , NC-1170 (CA-D*-ASC-6414-RR) and NRSP-8 National Animal Genome Research Support Program (CA-D*-ASC-7233-RR) . The authors thank Steve Oerding for assistance with graphic design of the ideogram. ",

year = "2010",

month = sep,

doi = "10.1016/j.exger.2010.04.002",

language = "English (US)",

volume = "45",

pages = "647--654",

journal = "Experimental Gerontology",

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T2 - A model for aging research

AU - Swanberg, Susan E.

AU - O'Hare, Thomas H.

AU - Robb, Elizabeth A.

AU - Robinson, Charmaine M.

AU - Chang, Hong

AU - Delany, Mary E.

N1 - Funding Information: Supported by the National Research Initiative Grant no. 2005-35205-16679 from the USDA National Institute of Food and Agriculture (NIFA) Animal Genome program and NIFA Multistate Research Projects NE-1034 (CA-D*-ASC-7281-RR) , NC-1170 (CA-D*-ASC-6414-RR) and NRSP-8 National Animal Genome Research Support Program (CA-D*-ASC-7233-RR) . The authors thank Steve Oerding for assistance with graphic design of the ideogram.

PY - 2010/9

Y1 - 2010/9

N2 - Division-dependent telomere shortening correlating with age triggers senescence on a cellular level and telomere dysfunction can facilitate oncogenesis. Therefore, the study of telomere biology is critical to the understanding of aging and cancer. The domestic chicken, a classic model for the study of developmental biology, possesses a telomere genome with highly conserved aspects and distinctive features which make it uniquely suited for the study of telomere maintenance mechanisms, their function and dysfunction. The purpose of this review is to highlight the chicken as a model for aging research, specifically as a model for telomere and telomerase research, and to increase its utility as such by describing developments in the study of chicken telomeres and telomerase in the context of related research in human and mouse.

AB - Division-dependent telomere shortening correlating with age triggers senescence on a cellular level and telomere dysfunction can facilitate oncogenesis. Therefore, the study of telomere biology is critical to the understanding of aging and cancer. The domestic chicken, a classic model for the study of developmental biology, possesses a telomere genome with highly conserved aspects and distinctive features which make it uniquely suited for the study of telomere maintenance mechanisms, their function and dysfunction. The purpose of this review is to highlight the chicken as a model for aging research, specifically as a model for telomere and telomerase research, and to increase its utility as such by describing developments in the study of chicken telomeres and telomerase in the context of related research in human and mouse.

KW - DF-1

KW - DT40

KW - Mega-telomeres

KW - Reconstitution of telomerase

KW - Splice variants

KW - Telomerase

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KW - TERT

KW - TR

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Telomere biology of the chicken: A model for aging research

Abstract

Keywords

ASJC Scopus subject areas

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