TCR signaling emerges from the sum of many parts

"How does T cell receptor signaling begin?" Answering this question requires an understandingof how the parts of the molecular machinery that mediates this process fit andwork together. Ultimately this molecular architecture must (i) trigger the relay of informationfrom the TCR-pMHC interface to the signaling substrates of the CD3 molecules and(ii) bring the kinases that modify these substrates in close proximity to interact, initiate,and sustain signaling. In this contribution we will discuss advances of the last decade thathave increased our understanding of the complex machinery and interactions that underliethis type of signaling.