Targeting PIM Kinases to Improve the Efficacy of Immunotherapy

Amber N. Clements; Noel A. Warfel

doi:10.3390/cells11223700

Targeting PIM Kinases to Improve the Efficacy of Immunotherapy

Amber N. Clements, Noel A. Warfel

Cellular and Molecular Medicine

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of serine/threonine kinases that regulates numerous signaling networks that promote cell growth, proliferation, and survival. PIM kinases are commonly upregulated in both solid tumors and hematological malignancies. Recent studies have demonstrated that PIM facilitates immune evasion in cancer by promoting an immunosuppressive tumor microenvironment that suppresses the innate anti-tumor response. The role of PIM in immune evasion has sparked interest in examining the effect of PIM inhibition in combination with immunotherapy. This review focuses on the role of PIM kinases in regulating immune cell populations, how PIM modulates the immune tumor microenvironment to promote immune evasion, and how PIM inhibitors may be used to enhance the efficacy of immunotherapy.

Original language	English (US)
Article number	3700
Journal	Cells
Volume	11
Issue number	22
DOIs	https://doi.org/10.3390/cells11223700
State	Published - Nov 2022

Keywords

PIM kinase
immunotherapy
inflammation

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.3390/cells11223700

Cite this

@article{7fee27d8b8754e04a71dcedaa24816ed,

title = "Targeting PIM Kinases to Improve the Efficacy of Immunotherapy",

abstract = "The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of serine/threonine kinases that regulates numerous signaling networks that promote cell growth, proliferation, and survival. PIM kinases are commonly upregulated in both solid tumors and hematological malignancies. Recent studies have demonstrated that PIM facilitates immune evasion in cancer by promoting an immunosuppressive tumor microenvironment that suppresses the innate anti-tumor response. The role of PIM in immune evasion has sparked interest in examining the effect of PIM inhibition in combination with immunotherapy. This review focuses on the role of PIM kinases in regulating immune cell populations, how PIM modulates the immune tumor microenvironment to promote immune evasion, and how PIM inhibitors may be used to enhance the efficacy of immunotherapy.",

keywords = "PIM kinase, immunotherapy, inflammation",

author = "Clements, {Amber N.} and Warfel, {Noel A.}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = nov,

doi = "10.3390/cells11223700",

language = "English (US)",

volume = "11",

journal = "Cells",

issn = "2073-4409",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "22",

}

TY - JOUR

T1 - Targeting PIM Kinases to Improve the Efficacy of Immunotherapy

AU - Clements, Amber N.

AU - Warfel, Noel A.

PY - 2022/11

Y1 - 2022/11

N2 - The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of serine/threonine kinases that regulates numerous signaling networks that promote cell growth, proliferation, and survival. PIM kinases are commonly upregulated in both solid tumors and hematological malignancies. Recent studies have demonstrated that PIM facilitates immune evasion in cancer by promoting an immunosuppressive tumor microenvironment that suppresses the innate anti-tumor response. The role of PIM in immune evasion has sparked interest in examining the effect of PIM inhibition in combination with immunotherapy. This review focuses on the role of PIM kinases in regulating immune cell populations, how PIM modulates the immune tumor microenvironment to promote immune evasion, and how PIM inhibitors may be used to enhance the efficacy of immunotherapy.

AB - The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of serine/threonine kinases that regulates numerous signaling networks that promote cell growth, proliferation, and survival. PIM kinases are commonly upregulated in both solid tumors and hematological malignancies. Recent studies have demonstrated that PIM facilitates immune evasion in cancer by promoting an immunosuppressive tumor microenvironment that suppresses the innate anti-tumor response. The role of PIM in immune evasion has sparked interest in examining the effect of PIM inhibition in combination with immunotherapy. This review focuses on the role of PIM kinases in regulating immune cell populations, how PIM modulates the immune tumor microenvironment to promote immune evasion, and how PIM inhibitors may be used to enhance the efficacy of immunotherapy.

KW - PIM kinase

KW - immunotherapy

KW - inflammation

UR - http://www.scopus.com/inward/record.url?scp=85142419406&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85142419406&partnerID=8YFLogxK

U2 - 10.3390/cells11223700

DO - 10.3390/cells11223700

M3 - Review article

AN - SCOPUS:85142419406

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

IS - 22

M1 - 3700

ER -

Targeting PIM Kinases to Improve the Efficacy of Immunotherapy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this