Targeting iron to contrast cancer progression

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1 Scopus citations

Abstract

An altered metabolism of iron fuels cancer growth, invasion, metastasis, and recurrence. Ongoing research in cancer biology is delineating a complex iron-trafficking program involving both malignant cells and their support network of cancer stem cells, immune cells, and other stromal components in the tumor microenvironment. Iron-binding strategies in anticancer drug discovery are being pursued in clinical trials and in multiple programs at various levels of development. Polypharmacological mechanisms of action, combined with emerging iron-associated biomarkers and companion diagnostics, are poised to offer new therapeutic options. By targeting a fundamental player in cancer progression, iron-binding drug candidates (either alone or in combination therapy) have the potential to impact a broad range of cancer types and to address the major clinical problems of recurrence and resistance to therapy.

Original languageEnglish (US)
Article number102315
JournalCurrent Opinion in Chemical Biology
Volume74
DOIs
StatePublished - Jun 2023
Externally publishedYes

Keywords

  • Cancer
  • Chelator
  • Iron
  • Macrophage
  • Prochelator
  • Stemness
  • Tumor microenvironment

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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