Targeted therapies for prostate cancer

Ekatherine Asatiani, Edward P. Gelman

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


The development of targeted therapies for prostate cancer has exploited various elements of prostate biology. The androgen-dependence of prostate cancer continues to be the focus for the development of new drugs and the analysis of details of the intermolecular interactions of the androgen receptor. Importantly, new applications of androgen ablation therapy have proven to have the greatest effect on cause-specific and overall survival during the last decade. Prostate epithelial cells express a number of tissue-specific proteins that have been the target either for antibody-directed therapies, in the case of prostate-specific membrane antigen, or target-activated therapies in the case of prostate-specific antigen, a serine protease. Prostate-specific proteins have also been targeted by the development of vaccines that have entered clinical trials. Humanised monoclonal antibodies and small molecules designed to inhibit oncogenic signalling pathways have been subjected to clinical trials in prostate cancer with limited success. The application of pathway inhibitors to prostate cancer therapy has been limited because no common dominant oncogenic mutation affecting signal kinase activation in prostate cancer has yet been identified. The interaction of signal kinase inhibitors with androgen ablation and with cytotoxic chemotherapy remains to be explored.

Original languageEnglish (US)
Pages (from-to)283-298
Number of pages16
JournalExpert Opinion on Therapeutic Targets
Issue number2
StatePublished - Apr 2005
Externally publishedYes


  • Prostate cancer
  • Prostate-specific antigen (PSA)
  • Prostate-specific membrane antigen (PSMA)
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


Dive into the research topics of 'Targeted therapies for prostate cancer'. Together they form a unique fingerprint.

Cite this