Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease [14]

Marcia M. Shull; Ilona Ormsby; Ann B. Kier; Sharon Pawlowski; Ronald J. Diebold; Moying Yin; Ruth Allen; Charles Sidman; Gabriele Proetzel; Dawn Calvin; Nikki Annunziata; Thomas Doetschman

doi:10.1038/359693a0

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease [14]

Marcia M. Shull, Ilona Ormsby, Ann B. Kier, Sharon Pawlowski, Ronald J. Diebold, Moying Yin, Ruth Allen, Charles Sidman, Gabriele Proetzel, Dawn Calvin, Nikki Annunziata, Thomas Doetschman

Cellular and Molecular Medicine

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Abstract

Transforming growth factor-β1 (TGF-β1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-β1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-β1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-β1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.

Original language	English (US)
Pages (from-to)	693-699
Number of pages	7
Journal	Nature
Volume	359
Issue number	6397
DOIs	https://doi.org/10.1038/359693a0
State	Published - 1992

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title = "Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease [14]",

abstract = "Transforming growth factor-β1 (TGF-β1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-β1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-β1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-β1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.",

author = "Shull, {Marcia M.} and Ilona Ormsby and Kier, {Ann B.} and Sharon Pawlowski and Diebold, {Ronald J.} and Moying Yin and Ruth Allen and Charles Sidman and Gabriele Proetzel and Dawn Calvin and Nikki Annunziata and Thomas Doetschman",

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doi = "10.1038/359693a0",

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T1 - Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease [14]

AU - Shull, Marcia M.

AU - Ormsby, Ilona

AU - Kier, Ann B.

AU - Pawlowski, Sharon

AU - Diebold, Ronald J.

AU - Yin, Moying

AU - Allen, Ruth

AU - Sidman, Charles

AU - Proetzel, Gabriele

AU - Calvin, Dawn

AU - Annunziata, Nikki

AU - Doetschman, Thomas

PY - 1992

Y1 - 1992

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AB - Transforming growth factor-β1 (TGF-β1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-β1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-β1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-β1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.

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Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease [14]

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