@article{5c77ce4d95a14464aeb2d50f1278a8b1,
title = "Taq1a polymorphism (rs1800497) is associated with obesity-related outcomes and dietary intake in a multi-ethnic sample of children",
abstract = "Background: In adults, the Taq1a polymorphism (rs1800497) near the D2 receptor (DRD2) gene is associated with body mass index and binge eating and is more prevalent among non-Hispanic Blacks (NHB) and Hispanic–Americans (HA) relative to non-Hispanic Whites (NHW). We hypothesize Taq1a polymorphism (rs1800497) risk alleles contribute to paediatric racial/ethnic differences in obesity phenotypes. Objectives: This study aims to characterize the relationship between the Taq1a polymorphism (rs1800497), diet and adiposity in a multi-ethnic cohort of 286 children (98 NHB, 76 HA and 112 NHW), ages 7–12. Methods: Dual-energy X-ray absorptiometry, computed tomography scans and two 24-h dietary recalls assessed body composition, fat distribution and dietary intakes, respectively. Results: Children with two Taq1a risk alleles (NHB = 50.0%, HA = 43.3%, NHW = 6.7%) reported a 20% increase in total energy intake (P = 0.0034) and per cent of calories from sugar consumed (P = 0.0077) than did children with less than two risk alleles. Children with two Taq1a risk alleles demonstrated significantly higher total body fat (P = 0.0145), body fat percentage (P = 0.0377), intra-abdominal adiposity (P = 0.0459), subcutaneous abdominal adiposity (P = 0.0213) and total abdominal adiposity (P = 0.0209) than did children with one or no Taq1a risk alleles. Conclusions: Our results suggest that having two Taq1a risk alleles is associated with an increase in reported calorie and sugar consumption and is a potential risk factor for early development of excess adiposity in multi-ethnic children. These results need to be confirmed in a larger sample.",
keywords = "DRD2, SNPs, adiposity, dopamine",
author = "Cardel, {M. I.} and Lemas, {D. J.} and Lee, {A. M.} and Miller, {D. R.} and T. Huo and Klimentidis, {Y. C.} and Fernandez, {J. R.}",
note = "Funding Information: This research was supported by National Institutes of Health (NIH) grants R01DK067426, R01DK51684 and R01DK49779; NIH Cancer Prevention and Control Training Program CA47888; NIH CURE Supplement Cancer Prevention and Control Training Program CA3R25CA047888; NIH National Institute of Diabetes and Digestive and Kidney Diseases T32 DK007658-21; General Clinical Research Center grant M01RR000032 from the National Center for Research Resources; and Nutrition Obesity Research Center grant P30DK56336. Dr. Cardel is supported by the National Institutes of Health National Heart, Lung, and Blood Institute (R25HL126146, R01HL120960 and K01HL141535) and the National Center For Advancing Translational Sciences of the National Institutes of Health (UL1TR001427). Funding Information: This research was supported by National Institutes of Health (NIH) grants R01DK067426, R01DK51684 and R01DK49779; NIH Cancer Prevention and Control Training Program CA47888; NIH CURE Supplement Cancer Prevention and Control Training Program CA3R25CA047888; NIH National Institute of Diabetes and Digestive and Kidney Diseases T32 DK007658-21; General Clinical Research Center grant M01RR000032 from the National Center for Research Resources; and Nutrition Obesity Research Center grant P30DK56336. Dr. Cardel is supported by the National Institutes of Health National Heart, Lung, and Blood Institute (R25HL126146, R01HL120960 and K01HL141535) and the National Center For Advancing Translational Sciences of the National Institutes of Health (UL1TR001427). MIC, DJL, YCK and JRF designed the research (project conception, development of overall research plan and study oversight). MIC and JRF conducted the research (hands-on conduct of the experiments and data collection). MIC, DJL, YCK and TH analyzsd data or performed statistical analysis. MIC, DJL, AML, DRM, YCK and JRF interpreted data findings. MIC, DJL, AML, DRM and JRF wrote paper. MIC and JRF had primary responsibility for final content. All authors have read and approved the final manuscript. Publisher Copyright: {\textcopyright} 2018 World Obesity Federation",
year = "2019",
month = feb,
doi = "10.1111/ijpo.12470",
language = "English (US)",
volume = "14",
journal = "Pediatric Obesity",
issn = "2047-6302",
publisher = "Wiley-Blackwell for the International Association for the Study of Obesity",
number = "2",
}