TY - JOUR
T1 - T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1
AU - Trad, Malika
AU - Gautheron, Alexandrine
AU - Fraszczak, Jennifer
AU - Alizadeh, Darya
AU - Larmonier, Claire
AU - Lacasse, Collin J.
AU - Centuori, Sara
AU - Audia, Sylvain
AU - Samson, Maxime
AU - Ciudad, Marion
AU - Bonnefoy, Francis
AU - Lemaire-Ewing, Stéphanie
AU - Katsanis, Emmanuel
AU - Perruche, Sylvain
AU - Saas, Philippe
AU - Bonnotte, Bernard
N1 - Publisher Copyright:
© 2015 Malika Trad et al.
PY - 2015
Y1 - 2015
N2 - T lymphocytes activated by dendritic cells (DC) which present tumor antigens play a key role in the antitumor immune response. However, in patients suffering from active cancer, DC are not efficient at initiating and supporting immune responses as they participate to T lymphocyte inhibition. DC in the tumor environment are functionally defective and exhibit a characteristic of immature phenotype, different to that of DC present in nonpathological conditions. The mechanistic bases underlying DC dysfunction in cancer responsible for the modulation of T-cell responses and tumor immune escape are still being investigated. Using two different mouse tumor models, we showed that tumor-infiltrating DC (TIDC) are constitutively immunosuppressive, exhibit a semimature phenotype, and impair responder T lymphocyte proliferation and activation by a mechanism involving CD39 ectoenzyme.
AB - T lymphocytes activated by dendritic cells (DC) which present tumor antigens play a key role in the antitumor immune response. However, in patients suffering from active cancer, DC are not efficient at initiating and supporting immune responses as they participate to T lymphocyte inhibition. DC in the tumor environment are functionally defective and exhibit a characteristic of immature phenotype, different to that of DC present in nonpathological conditions. The mechanistic bases underlying DC dysfunction in cancer responsible for the modulation of T-cell responses and tumor immune escape are still being investigated. Using two different mouse tumor models, we showed that tumor-infiltrating DC (TIDC) are constitutively immunosuppressive, exhibit a semimature phenotype, and impair responder T lymphocyte proliferation and activation by a mechanism involving CD39 ectoenzyme.
UR - http://www.scopus.com/inward/record.url?scp=84944235330&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84944235330&partnerID=8YFLogxK
U2 - 10.1155/2015/891236
DO - 10.1155/2015/891236
M3 - Article
C2 - 26491691
AN - SCOPUS:84944235330
SN - 2314-6133
VL - 2015
JO - BioMed research international
JF - BioMed research international
M1 - 891236
ER -