TY - JOUR
T1 - T cell aging
T2 - Naive but not young
AU - Nikolich-Žugich, Janko
PY - 2005/3/21
Y1 - 2005/3/21
N2 - The immune system exhibits profound age-related changes, collectively termed immunosenescence. The most visible of these is the decline in protective immunity, which results from a complex interaction of primary immune defects and compensatory homeostatic mechanisms. The sum of these changes is a dysregulation of many processes that normally ensure optimal immune function. Recent advances suggest that old mice can produce fully functional new T cells, opening both intriguing inquiry avenues and raising critical questions to be pursued.
AB - The immune system exhibits profound age-related changes, collectively termed immunosenescence. The most visible of these is the decline in protective immunity, which results from a complex interaction of primary immune defects and compensatory homeostatic mechanisms. The sum of these changes is a dysregulation of many processes that normally ensure optimal immune function. Recent advances suggest that old mice can produce fully functional new T cells, opening both intriguing inquiry avenues and raising critical questions to be pursued.
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U2 - 10.1084/jem.20050341
DO - 10.1084/jem.20050341
M3 - Review article
C2 - 15781575
AN - SCOPUS:17144411571
SN - 0022-1007
VL - 201
SP - 837
EP - 840
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 6
ER -