TY - JOUR
T1 - Systemic treatment of vitreous inflammation
AU - Christoforidis, John B.
AU - Chang, Susie
AU - Jiang, Angela
AU - Wang, Jillian
AU - Cebulla, Colleen M.
PY - 2012
Y1 - 2012
N2 - Non infectious vitreous inflammation is often vision threatening and can be associated with potentially life-threatening systemic conditions. Treatment is often challenging as it involves systemic medications that can be associated with adverse effects. The classes of drugs are ever expanding and include corticosteroids, antimetabolites, alkylating agents, T-cell and calcineurin agents, biologic agents, and interferons. Each class of systemic therapy for non-infectious vitreous inflammation is reviewed. We discuss the mechanisms of action, usual clinical dosages, the specific conditions that are treated, the adverse effects, and usual course of treatment for each class of therapy.
AB - Non infectious vitreous inflammation is often vision threatening and can be associated with potentially life-threatening systemic conditions. Treatment is often challenging as it involves systemic medications that can be associated with adverse effects. The classes of drugs are ever expanding and include corticosteroids, antimetabolites, alkylating agents, T-cell and calcineurin agents, biologic agents, and interferons. Each class of systemic therapy for non-infectious vitreous inflammation is reviewed. We discuss the mechanisms of action, usual clinical dosages, the specific conditions that are treated, the adverse effects, and usual course of treatment for each class of therapy.
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U2 - 10.1155/2012/936721
DO - 10.1155/2012/936721
M3 - Review article
C2 - 23028205
AN - SCOPUS:84867818487
SN - 0962-9351
VL - 2012
JO - Mediators of Inflammation
JF - Mediators of Inflammation
M1 - 936721
ER -