Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids

Francis N. Murigi; Gary S. Nichol; Eugene A. Mash

doi:10.1021/jo902438s

Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids

Francis N. Murigi, Gary S. Nichol, Eugene A. Mash

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

(Chemical Equation Presented) The conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids, were prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L-phenylalanine. Absolute configurations were assigned by X-ray crystallographic analysis.

Original language	English (US)
Pages (from-to)	1293-1296
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	75
Issue number	4
DOIs	https://doi.org/10.1021/jo902438s
State	Published - Feb 19 2010

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo902438s

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title = "Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids",

abstract = "(Chemical Equation Presented) The conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids, were prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L-phenylalanine. Absolute configurations were assigned by X-ray crystallographic analysis.",

author = "Murigi, {Francis N.} and Nichol, {Gary S.} and Mash, {Eugene A.}",

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T1 - Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids

AU - Murigi, Francis N.

AU - Nichol, Gary S.

AU - Mash, Eugene A.

PY - 2010/2/19

Y1 - 2010/2/19

N2 - (Chemical Equation Presented) The conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids, were prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L-phenylalanine. Absolute configurations were assigned by X-ray crystallographic analysis.

AB - (Chemical Equation Presented) The conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids, were prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L-phenylalanine. Absolute configurations were assigned by X-ray crystallographic analysis.

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Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids

Abstract

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CCDC 812882: Experimental Crystal Structure Determination

CCDC 812881: Experimental Crystal Structure Determination

Cite this

Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids

Abstract

ASJC Scopus subject areas

Access to Document

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Fingerprint

Datasets

CCDC 812882: Experimental Crystal Structure Determination

CCDC 812881: Experimental Crystal Structure Determination

Cite this