Synthesis of taxol from baccatin III via an oxazoline intermediate

David G.I. Kingston; Ashok G. Chaudhary; A. A.Leslie Gunatilaka; Mark L. Middleton

doi:10.1016/S0040-4039(00)60706-2

Synthesis of taxol from baccatin III via an oxazoline intermediate

David G.I. Kingston
, Ashok G. Chaudhary
, A. A.Leslie Gunatilaka
, Mark L. Middleton

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Taxol (1) can be prepared in good yield by coupling the oxazoline carboxylic acid 5 with 7-(triethylsilyl)baccatin III, followed by hydrolysis. The oxazolines 7 and 8 can also be prepared directly from taxol.

Original language	English (US)
Pages (from-to)	4483-4484
Number of pages	2
Journal	Tetrahedron Letters
Volume	35
Issue number	26
DOIs	https://doi.org/10.1016/S0040-4039(00)60706-2
State	Published - Jun 27 1994
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)60706-2

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@article{9545482cdb684378a66607e75519eb46,

title = "Synthesis of taxol from baccatin III via an oxazoline intermediate",

abstract = "Taxol (1) can be prepared in good yield by coupling the oxazoline carboxylic acid 5 with 7-(triethylsilyl)baccatin III, followed by hydrolysis. The oxazolines 7 and 8 can also be prepared directly from taxol.",

author = "Kingston, \{David G.I.\} and Chaudhary, \{Ashok G.\} and Gunatilaka, \{A. A.Leslie\} and Middleton, \{Mark L.\}",

year = "1994",

month = jun,

day = "27",

doi = "10.1016/S0040-4039(00)60706-2",

language = "English (US)",

volume = "35",

pages = "4483--4484",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "26",

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TY - JOUR

T1 - Synthesis of taxol from baccatin III via an oxazoline intermediate

AU - Kingston, David G.I.

AU - Chaudhary, Ashok G.

AU - Gunatilaka, A. A.Leslie

AU - Middleton, Mark L.

PY - 1994/6/27

Y1 - 1994/6/27

N2 - Taxol (1) can be prepared in good yield by coupling the oxazoline carboxylic acid 5 with 7-(triethylsilyl)baccatin III, followed by hydrolysis. The oxazolines 7 and 8 can also be prepared directly from taxol.

AB - Taxol (1) can be prepared in good yield by coupling the oxazoline carboxylic acid 5 with 7-(triethylsilyl)baccatin III, followed by hydrolysis. The oxazolines 7 and 8 can also be prepared directly from taxol.

UR - https://www.scopus.com/pages/publications/0028232538

UR - https://www.scopus.com/pages/publications/0028232538#tab=citedBy

U2 - 10.1016/S0040-4039(00)60706-2

DO - 10.1016/S0040-4039(00)60706-2

M3 - Article

AN - SCOPUS:0028232538

SN - 0040-4039

VL - 35

SP - 4483

EP - 4484

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 26

ER -

Synthesis of taxol from baccatin III via an oxazoline intermediate

Abstract

ASJC Scopus subject areas

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