Synthesis of taxol from baccatin III via an oxazoline intermediate

David G.I. Kingston, Ashok G. Chaudhary, A. A.Leslie Gunatilaka, Mark L. Middleton

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Taxol (1) can be prepared in good yield by coupling the oxazoline carboxylic acid 5 with 7-(triethylsilyl)baccatin III, followed by hydrolysis. The oxazolines 7 and 8 can also be prepared directly from taxol.

Original languageEnglish (US)
Pages (from-to)4483-4484
Number of pages2
JournalTetrahedron Letters
Issue number26
StatePublished - Jun 27 1994

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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