Synthesis of 15N‐1 nicotinamide. A general, one step synthesis of 15N labeled pyridine heterocycles

Norman J. Oppenheimer; Terry O. Matsunaga; Bernard L. Kam

doi:10.1002/jlcr.2580150126

Synthesis of ¹⁵N‐1 nicotinamide. A general, one step synthesis of ¹⁵N labeled pyridine heterocycles

Norman J. Oppenheimer, Terry O. Matsunaga, Bernard L. Kam

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A one step, high yield synthesis is reported of ¹⁵N‐1 nicotinamide from the reaction of ¹⁵N ammonia with 1‐N‐(2,4‐dinitrobenzene)‐3‐carbamoyl‐pyridinium chloride. This reaction represents a specific example of a general and facile method for the synthesis of a wide variety of ¹⁵N labeled pyridine heterocycles.

Original language	English (US)
Pages (from-to)	191-196
Number of pages	6
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	15
Issue number	1 S
DOIs	https://doi.org/10.1002/jlcr.2580150126
State	Published - Oct 1978
Externally published	Yes

Keywords

N‐1 Nicotinamide

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.2580150126

Cite this

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abstract = "A one step, high yield synthesis is reported of 15N‐1 nicotinamide from the reaction of 15N ammonia with 1‐N‐(2,4‐dinitrobenzene)‐3‐carbamoyl‐pyridinium chloride. This reaction represents a specific example of a general and facile method for the synthesis of a wide variety of 15N labeled pyridine heterocycles.",

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