Synthesis of [14C]-imexon

Bhumasamudram Jagadish; Bhashyam S. Iyengar; Anikó M. Sólyom; William A. Remers; Robert T Dorr; Jason Shin Yu; Surendra Gupta; Eugene A. Mash

doi:10.1002/jlcr.911

Synthesis of [¹⁴C]-imexon

Bhumasamudram Jagadish, Bhashyam S. Iyengar, Anikó M. Sólyom, William A. Remers, Robert T Dorr, Jason Shin Yu, Surendra Gupta, Eugene A. Mash

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A four-step synthesis of [¹⁴C]-imexon is described, starting from [¹⁴C]-phosgene. The overall yield is 27% and the specific activity is 55 mCi/mmol.

Original language	English (US)
Pages (from-to)	165-170
Number of pages	6
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	48
Issue number	3
DOIs	https://doi.org/10.1002/jlcr.911
State	Published - Mar 2005

Keywords

Anticancer agent
Aziridine
Imexon
Sulfhydryl-binding

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.911

Cite this

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title = "Synthesis of [14C]-imexon",

abstract = "A four-step synthesis of [14C]-imexon is described, starting from [14C]-phosgene. The overall yield is 27% and the specific activity is 55 mCi/mmol.",

keywords = "Anticancer agent, Aziridine, Imexon, Sulfhydryl-binding",

author = "Bhumasamudram Jagadish and Iyengar, {Bhashyam S.} and S{\'o}lyom, {Anik{\'o} M.} and Remers, {William A.} and Dorr, {Robert T} and Yu, {Jason Shin} and Surendra Gupta and Mash, {Eugene A.}",

year = "2005",

month = mar,

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language = "English (US)",

volume = "48",

pages = "165--170",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

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AU - Jagadish, Bhumasamudram

AU - Iyengar, Bhashyam S.

AU - Sólyom, Anikó M.

AU - Remers, William A.

AU - Dorr, Robert T

AU - Yu, Jason Shin

AU - Gupta, Surendra

AU - Mash, Eugene A.

PY - 2005/3

Y1 - 2005/3

N2 - A four-step synthesis of [14C]-imexon is described, starting from [14C]-phosgene. The overall yield is 27% and the specific activity is 55 mCi/mmol.

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KW - Aziridine

KW - Imexon

KW - Sulfhydryl-binding

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