Abstract
Syntheses of [13C6]-2,4-dinitroanisole (ring- 13C6) from [13C6]-anisole (ring-13C6) and [15N2]-2,4- dinitroanisole from anisole using in situ generated acetyl nitrate and [ 15N]-acetyl nitrate, respectively, are described. Treatment of [ 13C6]-anisole (ring-13C6) with acetyl nitrate generated in 100% HNO3 gave [13C 6]-2,4-dinitroanisole (ring-13C6) in 83% yield. Treatment of anisole with [15N]-acetyl nitrate generated in 10 N [15N]-HNO3 gave [15N2]-2,4- dinitroanisole in 44% yield after two cycles of nitration. Byproducts in the latter reaction included [15N]-2-nitroanisole and [ 15N]-4-nitroanisole.
Original language | English (US) |
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Pages (from-to) | 434-436 |
Number of pages | 3 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 57 |
Issue number | 6 |
DOIs | |
State | Published - May 30 2014 |
Keywords
- insensitive munitions compounds
- synthesis
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry