Synthesis of Pyridodiindoles with Anticancer Activity by a Three-Component Cascade Condensation

Zhong Zhu Chen; Shi Qiang Li; Ya Jun Zhang; Dian Yong Tang; Jiang Ping Meng; Jie Lei; Hong Yu Li; Zhi Gang Xu

doi:10.1021/acs.orglett.8b03245

Synthesis of Pyridodiindoles with Anticancer Activity by a Three-Component Cascade Condensation

Zhong Zhu Chen
, Shi Qiang Li
, Ya Jun Zhang
, Dian Yong Tang
, Jiang Ping Meng
, Jie Lei
, Hong Yu Li
, Zhi Gang Xu

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A novel three-component cascade reaction was discovered and developed to synthesize pyridodiindoles with the assistance of microwave irradiation. A collection of pyridodiindoles was prepared by means of the mild reaction and simple operation procedure, which could be applicable to a broad scope of functional aldehydes. Screening demonstrated that compound 5g exhibited a good potency in HCT116 cell lines, and this work validated the feasibility of this novel reaction for generating promising bioactive compounds.

Original language	English (US)
Pages (from-to)	7811-7815
Number of pages	5
Journal	Organic Letters
Volume	20
Issue number	24
DOIs	https://doi.org/10.1021/acs.orglett.8b03245
State	Published - Dec 21 2018

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.8b03245

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title = "Synthesis of Pyridodiindoles with Anticancer Activity by a Three-Component Cascade Condensation",

abstract = "A novel three-component cascade reaction was discovered and developed to synthesize pyridodiindoles with the assistance of microwave irradiation. A collection of pyridodiindoles was prepared by means of the mild reaction and simple operation procedure, which could be applicable to a broad scope of functional aldehydes. Screening demonstrated that compound 5g exhibited a good potency in HCT116 cell lines, and this work validated the feasibility of this novel reaction for generating promising bioactive compounds.",

author = "Chen, \{Zhong Zhu\} and Li, \{Shi Qiang\} and Zhang, \{Ya Jun\} and Tang, \{Dian Yong\} and Meng, \{Jiang Ping\} and Jie Lei and Li, \{Hong Yu\} and Xu, \{Zhi Gang\}",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

year = "2018",

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doi = "10.1021/acs.orglett.8b03245",

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T1 - Synthesis of Pyridodiindoles with Anticancer Activity by a Three-Component Cascade Condensation

AU - Chen, Zhong Zhu

AU - Li, Shi Qiang

AU - Zhang, Ya Jun

AU - Tang, Dian Yong

AU - Meng, Jiang Ping

AU - Lei, Jie

AU - Li, Hong Yu

AU - Xu, Zhi Gang

PY - 2018/12/21

Y1 - 2018/12/21

N2 - A novel three-component cascade reaction was discovered and developed to synthesize pyridodiindoles with the assistance of microwave irradiation. A collection of pyridodiindoles was prepared by means of the mild reaction and simple operation procedure, which could be applicable to a broad scope of functional aldehydes. Screening demonstrated that compound 5g exhibited a good potency in HCT116 cell lines, and this work validated the feasibility of this novel reaction for generating promising bioactive compounds.

AB - A novel three-component cascade reaction was discovered and developed to synthesize pyridodiindoles with the assistance of microwave irradiation. A collection of pyridodiindoles was prepared by means of the mild reaction and simple operation procedure, which could be applicable to a broad scope of functional aldehydes. Screening demonstrated that compound 5g exhibited a good potency in HCT116 cell lines, and this work validated the feasibility of this novel reaction for generating promising bioactive compounds.

UR - https://www.scopus.com/pages/publications/85059689654

UR - https://www.scopus.com/pages/publications/85059689654#tab=citedBy

U2 - 10.1021/acs.orglett.8b03245

DO - 10.1021/acs.orglett.8b03245

M3 - Article

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AN - SCOPUS:85059689654

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SP - 7811

EP - 7815

JO - Organic Letters

JF - Organic Letters

IS - 24

ER -

Synthesis of Pyridodiindoles with Anticancer Activity by a Three-Component Cascade Condensation

Abstract

ASJC Scopus subject areas

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