@article{27298091e8314b71954a2c8c08054ae4,
title = "Synthesis of Pyridodiindoles with Anticancer Activity by a Three-Component Cascade Condensation",
abstract = "A novel three-component cascade reaction was discovered and developed to synthesize pyridodiindoles with the assistance of microwave irradiation. A collection of pyridodiindoles was prepared by means of the mild reaction and simple operation procedure, which could be applicable to a broad scope of functional aldehydes. Screening demonstrated that compound 5g exhibited a good potency in HCT116 cell lines, and this work validated the feasibility of this novel reaction for generating promising bioactive compounds.",
author = "Chen, {Zhong Zhu} and Li, {Shi Qiang} and Zhang, {Ya Jun} and Tang, {Dian Yong} and Meng, {Jiang Ping} and Jie Lei and Li, {Hong Yu} and Xu, {Zhi Gang}",
note = "Funding Information: We thank the Science and Technology Research Program of Chongqing Municipal Education Commission (KJZH17129, KJQN201801321, KJZD-M201801301), the Natural Science Foundation Project of CQ CSTSC (CSTC2015ZDCY-ZTZX120003, cstc2018jszx-cyzd0110, and cstc2018jszx-cyzdX0023), and the Scientific Research Foundation of the Chongqing University of Arts and Sciences (Z2016BX02). H.L. was supported by the grants NIH 1R01CA194094-010 and 1R01CA197178-01A1 and UAMS start-up funding. We also thank Ms. H. Z. Liu and J. Xu for obtaining the LC/MS, HRMS, and NMR data. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = dec,
day = "21",
doi = "10.1021/acs.orglett.8b03245",
language = "English (US)",
volume = "20",
pages = "7811--7815",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "24",
}