Synthesis of Indolizines via Reaction of 2-Substitued Azaarenes with Enals by an Amine-NHC Relay Catalysis

Hongxian Li, Xiangmin Li, Yang Yu, Jianjun Li, Yuan Liu, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

A metal-free catalytic strategy for the facile synthesis of biologically relevant molecular architectures indolizines and imidazopyridines has been developed. The process is promoted by amine and N-heterocyclic carbene (NHC) relay catalysis via Michael addition-[3 + 2] fusion of simple azaarenes and α,β-unsaturated aldehydes. The preparative power is demonstrated in the synthesis of anxiolytic drug saripidem via two simple one-pot operations with overall 45% yield.

Original languageEnglish (US)
Pages (from-to)2010-2013
Number of pages4
JournalOrganic Letters
Volume19
Issue number8
DOIs
StatePublished - Apr 21 2017
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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