Abstract
(Chemical Equation Presented) Do a double take: A novel highly enantio-and diastereoselective cascade double Michael reaction, in which two C-C bonds and three contiguous stereogenic centers are formed, has been developed. The one-pot process, which was efficiently catalyzed by the chiral diphenylprolinyl trimethylsilyl (TMS) ether, is a facile approach to synthetically useful chiral cyclopentanes (see scheme).
Original language | English (US) |
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Pages (from-to) | 3732-3734 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 46 |
Issue number | 20 |
DOIs | |
State | Published - 2007 |
Externally published | Yes |
Keywords
- Aldehydes
- Cyclopentanes
- Domino reactions
- Michael addition
- Organocatalysis
ASJC Scopus subject areas
- Catalysis
- General Chemistry