Synthesis of ethyl N-(diphenyl)methyl-1,2,3,4- tetrahydroisoquinoline-3-carboxylates

Eugene A. Mash, Lawrence J. Williams, Steven S. Pfeiffer

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A concise method for the synthesis of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives from α,α'-dibromo-o-xylenes via sequential C-alkylation and N-alkylation of a glycine anion is described.

Original languageEnglish (US)
Pages (from-to)6977-6980
Number of pages4
JournalTetrahedron Letters
Issue number40
StatePublished - Oct 6 1997

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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