Abstract
The present study a series of (E)-5-methoxy-2-styryl-4H-pyran-4-ones 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j was synthesized and evaluated for growth inhibitory inhibition against carcinoma cells. The growth inhibition study of eight carcinoma cell lines was examined and demonstrated that SKHep cells exhibit significant structure-activity relationship in response to the tested compounds. Among them, 6f showed the most potent activity against SKHep, A549, AGS, and H460 cell lines with GI50 values of 0.17, 8.3, 3.6, 8.0 μM, respectively.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 56-61 |
| Number of pages | 6 |
| Journal | Journal of Heterocyclic Chemistry |
| Volume | 51 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2014 |
Keywords
- Arbuzov reaction
- Horner-Emmons reaction
- carcinoma cells
- growth-inhibitory agents
- kojic acid
ASJC Scopus subject areas
- Organic Chemistry
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