TY - JOUR
T1 - Synthesis of (E)-5-methoxy-2-styryl-4-pyrones as potent growth-inhibitory agents against hepatocellular carcinoma cells
AU - Chen, Yu Hua
AU - Lu, Pei Jung
AU - Hulme, Christopher
AU - Shaw, Arthur Y.
PY - 2014/1
Y1 - 2014/1
N2 - The present study a series of (E)-5-methoxy-2-styryl-4H-pyran-4-ones 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j was synthesized and evaluated for growth inhibitory inhibition against carcinoma cells. The growth inhibition study of eight carcinoma cell lines was examined and demonstrated that SKHep cells exhibit significant structure-activity relationship in response to the tested compounds. Among them, 6f showed the most potent activity against SKHep, A549, AGS, and H460 cell lines with GI50 values of 0.17, 8.3, 3.6, 8.0 μM, respectively.
AB - The present study a series of (E)-5-methoxy-2-styryl-4H-pyran-4-ones 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j was synthesized and evaluated for growth inhibitory inhibition against carcinoma cells. The growth inhibition study of eight carcinoma cell lines was examined and demonstrated that SKHep cells exhibit significant structure-activity relationship in response to the tested compounds. Among them, 6f showed the most potent activity against SKHep, A549, AGS, and H460 cell lines with GI50 values of 0.17, 8.3, 3.6, 8.0 μM, respectively.
KW - Arbuzov reaction
KW - Horner-Emmons reaction
KW - carcinoma cells
KW - growth-inhibitory agents
KW - kojic acid
UR - http://www.scopus.com/inward/record.url?scp=84894902219&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894902219&partnerID=8YFLogxK
U2 - 10.1002/jhet.1663
DO - 10.1002/jhet.1663
M3 - Article
AN - SCOPUS:84894902219
SN - 0022-152X
VL - 51
SP - 56
EP - 61
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 1
ER -