Abstract
(Chemical Presented) Functionally protected forms of three conformationally constrained diaminodicarboxylic acids were synthesized and characterized. 2,2′-Diaminospiro[3.3]heptane-2,2′-dicarboxylic acid, an analogue of diaminopimelic acid, was prepared in racemic form and the structure established by X-ray crystallographic analysis of the methyl ester hydrochloride. trans-1,4-Diaminocyclohexane-1,4-dicarboxylic acid was prepared and its structure established by X-ray crystallographic analysis of the corresponding Cbz-protected ethyl ester. cis- and trans-2,6-diamino-1,2,3,5,6,7-hexahydro- sindacene-2,6-dicarboxylic acids were synthesized and the structures assigned by X-ray crystallographic analysis of the corresponding Boc-protected ethyl ester and Cbz-protected ethyl ester, respectively.
Original language | English (US) |
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Pages (from-to) | 8773-8778 |
Number of pages | 6 |
Journal | Journal of Organic Chemistry |
Volume | 74 |
Issue number | 22 |
DOIs | |
State | Published - Nov 20 2009 |
ASJC Scopus subject areas
- Organic Chemistry
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CCDC 777215: Experimental Crystal Structure Determination
Weatherhead, R. A. (Creator), Carducci, M. D. (Creator) & Mash, E. A. (Creator), Cambridge Crystallographic Data Centre, 2010
DOI: 10.5517/ccv2rg3, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccv2rg3&sid=DataCite
Dataset
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CCDC 777213: Experimental Crystal Structure Determination
Weatherhead, R. A. (Creator), Carducci, M. D. (Creator) & Mash, E. A. (Creator), Cambridge Crystallographic Data Centre, 2010
DOI: 10.5517/ccv2rd1, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccv2rd1&sid=DataCite
Dataset
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CCDC 777214: Experimental Crystal Structure Determination
Weatherhead, R. A. (Creator), Carducci, M. D. (Creator) & Mash, E. A. (Creator), Cambridge Crystallographic Data Centre, 2010
DOI: 10.5517/ccv2rf2, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccv2rf2&sid=DataCite
Dataset