Synthesis of C-1 Deuterated 3-Formylindoles by Organophotoredox Catalyzed Direct Formylation of Indoles with Deuterated Glyoxylic Acid

Yue Dong, Xiangmin Li, Peng Ji, Feng Gao, Xiang Meng, Wei Wang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Direct formylation of feedstock indoles with newly developed, cost-effective deuterated glyoxylic acid as formylation agent under visible light and air (O2) as terminal oxidant has been developed. An isatin byproduct produced from the corresponding indole reactant serves as a facilitator for the formylation process. The simple, mild, metal- and oxidant-free protocol enables the synthesis of structurally diverse C1-deuterated 3-formylindoles with broad functional group tolerance and late-stage functionalization at a high level of D-incorporation (95-99%).

Original languageEnglish (US)
Pages (from-to)5034-5039
Number of pages6
JournalOrganic Letters
Volume24
Issue number28
DOIs
StatePublished - Jul 22 2022

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Synthesis of C-1 Deuterated 3-Formylindoles by Organophotoredox Catalyzed Direct Formylation of Indoles with Deuterated Glyoxylic Acid'. Together they form a unique fingerprint.

Cite this