Synthesis of 3-aminoindan-1-one derivatives from 2-acetylbenzaldehydes and secondary amines by Mannich annulation

Yong Zhang; Yonghai Liu; Shuai Zhang; Lei Shi; Wei Wang; Hao Li

doi:10.1016/j.tetlet.2019.04.035

Synthesis of 3-aminoindan-1-one derivatives from 2-acetylbenzaldehydes and secondary amines by Mannich annulation

Yong Zhang, Yonghai Liu, Shuai Zhang, Lei Shi, Wei Wang, Hao Li

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

An acid-promoted 2-component Mannich annulation reaction of readily available acetylbenzaldehydes and secondary amines has been reported. The approach provides a simple and efficient method under mild conditions to synthesize 3-aminoindan-1-one derivatives in moderate to good yields.

Original language	English (US)
Pages (from-to)	1463-1466
Number of pages	4
Journal	Tetrahedron Letters
Volume	60
Issue number	22
DOIs	https://doi.org/10.1016/j.tetlet.2019.04.035
State	Published - May 30 2019

Keywords

2-Acetylbenzaldehydes
3-Aminoindan-1-one
Annulation
Mannich

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2019.04.035

Cite this

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title = "Synthesis of 3-aminoindan-1-one derivatives from 2-acetylbenzaldehydes and secondary amines by Mannich annulation",

abstract = "An acid-promoted 2-component Mannich annulation reaction of readily available acetylbenzaldehydes and secondary amines has been reported. The approach provides a simple and efficient method under mild conditions to synthesize 3-aminoindan-1-one derivatives in moderate to good yields.",

keywords = "2-Acetylbenzaldehydes, 3-Aminoindan-1-one, Annulation, Mannich",

author = "Yong Zhang and Yonghai Liu and Shuai Zhang and Lei Shi and Wei Wang and Hao Li",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = may,

day = "30",

doi = "10.1016/j.tetlet.2019.04.035",

language = "English (US)",

volume = "60",

pages = "1463--1466",

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TY - JOUR

T1 - Synthesis of 3-aminoindan-1-one derivatives from 2-acetylbenzaldehydes and secondary amines by Mannich annulation

AU - Zhang, Yong

AU - Liu, Yonghai

AU - Zhang, Shuai

AU - Shi, Lei

AU - Wang, Wei

AU - Li, Hao

PY - 2019/5/30

Y1 - 2019/5/30

N2 - An acid-promoted 2-component Mannich annulation reaction of readily available acetylbenzaldehydes and secondary amines has been reported. The approach provides a simple and efficient method under mild conditions to synthesize 3-aminoindan-1-one derivatives in moderate to good yields.

AB - An acid-promoted 2-component Mannich annulation reaction of readily available acetylbenzaldehydes and secondary amines has been reported. The approach provides a simple and efficient method under mild conditions to synthesize 3-aminoindan-1-one derivatives in moderate to good yields.

KW - 2-Acetylbenzaldehydes

KW - 3-Aminoindan-1-one

KW - Annulation

KW - Mannich

UR - http://www.scopus.com/inward/record.url?scp=85065149335&partnerID=8YFLogxK

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U2 - 10.1016/j.tetlet.2019.04.035

DO - 10.1016/j.tetlet.2019.04.035

M3 - Article

AN - SCOPUS:85065149335

SN - 0040-4039

VL - 60

SP - 1463

EP - 1466

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 22

ER -

Synthesis of 3-aminoindan-1-one derivatives from 2-acetylbenzaldehydes and secondary amines by Mannich annulation

Abstract

Keywords

ASJC Scopus subject areas

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CCDC 1894243: Experimental Crystal Structure Determination

Cite this

Synthesis of 3-aminoindan-1-one derivatives from 2-acetylbenzaldehydes and secondary amines by Mannich annulation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Datasets

CCDC 1894243: Experimental Crystal Structure Determination

Cite this