Synthesis of 3-aminoindan-1-one derivatives from 2-acetylbenzaldehydes and secondary amines by Mannich annulation

Yong Zhang, Yonghai Liu, Shuai Zhang, Lei Shi, Wei Wang, Hao Li

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

An acid-promoted 2-component Mannich annulation reaction of readily available acetylbenzaldehydes and secondary amines has been reported. The approach provides a simple and efficient method under mild conditions to synthesize 3-aminoindan-1-one derivatives in moderate to good yields.

Original languageEnglish (US)
Pages (from-to)1463-1466
Number of pages4
JournalTetrahedron Letters
Volume60
Issue number22
DOIs
StatePublished - May 30 2019
Externally publishedYes

Keywords

  • 2-Acetylbenzaldehydes
  • 3-Aminoindan-1-one
  • Annulation
  • Mannich

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Synthesis of 3-aminoindan-1-one derivatives from 2-acetylbenzaldehydes and secondary amines by Mannich annulation'. Together they form a unique fingerprint.

Cite this