Synthesis of β-silyl α-amino acids via visible-light-mediated hydrosilylation

Yongqiang Zhang, Wei Wang, Yi Wan, Jiajie Zhu, Qiyang Yuan

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


An expedient synthesis of β-silyl α-amino acids is reported via the application of visible-light-mediated hydrosilylation. The reaction utilizes readily accessible and structurally diverse hydrosilanes to provide radicals for conjugate addition to dehydroalanine ester and analogues. Notably, the use of chiral methyleneoxazolidinone as the substrate and chiral inducer enabled the highly stereoselective synthesis. Furthermore, the reaction could also be performed in a continuous flow fashion and scaled up to the gram scale.

Original languageEnglish (US)
Pages (from-to)1406-1410
Number of pages5
JournalOrganic Letters
Issue number4
StatePublished - Feb 19 2021

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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