Abstract
(2S,3S)- and (2R,3R)-2-amino-3-phenyl-5-hexenoic acids have been synthesized in large scale by using Ni(II)-complexes as a template. The amino acids were used in the synthesis of [4,3,0]-bicyclic β-turn mimetics by a convergent methodology. The unique advantage of this strategy is the convenience of introducing side chain groups with predetermined chiralities on both the five- and six-membered heterocyclic rings.
Original language | English (US) |
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Pages (from-to) | 5863-5866 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 44 |
Issue number | 31 |
DOIs | |
State | Published - Jul 28 2003 |
Externally published | Yes |
Keywords
- Bicyclic dipeptide
- Ni(II)-complex
- β-side chain
- β-turn mimetic
- δ,ε-unsaturated amino acid
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry