Synthesis and structures of Zn(C6H12OS2)2(ClO 4)2 and Zn(C3H6NS2)2(C3 H4N2)- Model compounds for the Zn sites in RNA polymerase

Dong Chen; Linda Powers

doi:10.1016/0162-0134(94)00058-I

Synthesis and structures of Zn(C₆H₁₂OS₂)₂(ClO₄)₂ and Zn(C₃H₆NS₂)₂(C₃ H₄N₂)- Model compounds for the Zn sites in RNA polymerase

Dong Chen
, Linda Powers

Electrical and Computer Engineering

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Model compounds for the Zn sites of the β′ and the β subunits in RNA polymerase [1] were synthesized. Single crystal structures and X-ray absorption spectroscopy measurements for these two model complexes are reported. In Zn(C₆H₁₂OS₂)₂(ClO₄)₂, the Zn is coordinated by four sulfur and two oxygen atoms. The average ZnS bond length is 2.514 Å and the ZnO bond length is 2.089 Å, which are similar to these bond distances reported for the Zn site in the β′ subunit of RNA polymerase. In Zn(C₃H₆NS₂)₂(C₃ H₄N₂), the Zn atom is coordinated by four sulfur atoms and one nitrogen atom of an imidazole group. The average of the ZnS bond length is 2.469 Å and the ZnN bond length is 2.009 Å, which are also similar to the ZnS and ZnN bonds in the β subunits of RNA polymerase.

Original language	English (US)
Pages (from-to)	245-253
Number of pages	9
Journal	Journal of Inorganic Biochemistry
Volume	58
Issue number	4
DOIs	https://doi.org/10.1016/0162-0134(94)00058-I
State	Published - Jun 1995

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

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10.1016/0162-0134(94)00058-I

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@article{a6c804b7e9bb47398c670befa8ff17ae,

title = "Synthesis and structures of Zn(C6H12OS2)2(ClO 4)2 and Zn(C3H6NS2)2(C3 H4N2)- Model compounds for the Zn sites in RNA polymerase",

abstract = "Model compounds for the Zn sites of the β′ and the β subunits in RNA polymerase [1] were synthesized. Single crystal structures and X-ray absorption spectroscopy measurements for these two model complexes are reported. In Zn(C6H12OS2)2(ClO 4)2, the Zn is coordinated by four sulfur and two oxygen atoms. The average ZnS bond length is 2.514 {\AA} and the ZnO bond length is 2.089 {\AA}, which are similar to these bond distances reported for the Zn site in the β′ subunit of RNA polymerase. In Zn(C3H6NS2)2(C3 H4N2), the Zn atom is coordinated by four sulfur atoms and one nitrogen atom of an imidazole group. The average of the ZnS bond length is 2.469 {\AA} and the ZnN bond length is 2.009 {\AA}, which are also similar to the ZnS and ZnN bonds in the β subunits of RNA polymerase.",

author = "Dong Chen and Linda Powers",

note = "Funding Information: We thank Dr. J. L. Hubbard, of the Department of Chemistry and Biochemistry, Utah State University, for his help with the single crystal structures. The X-ray diffractometer was purchased with equal funding from the Natural Science Foundation (CHE-9002379) and the Utah State University Research Office.",

year = "1995",

month = jun,

doi = "10.1016/0162-0134(94)00058-I",

language = "English (US)",

volume = "58",

pages = "245--253",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Synthesis and structures of Zn(C6H12OS2)2(ClO 4)2 and Zn(C3H6NS2)2(C3 H4N2)- Model compounds for the Zn sites in RNA polymerase

AU - Chen, Dong

AU - Powers, Linda

N1 - Funding Information: We thank Dr. J. L. Hubbard, of the Department of Chemistry and Biochemistry, Utah State University, for his help with the single crystal structures. The X-ray diffractometer was purchased with equal funding from the Natural Science Foundation (CHE-9002379) and the Utah State University Research Office.

PY - 1995/6

Y1 - 1995/6

N2 - Model compounds for the Zn sites of the β′ and the β subunits in RNA polymerase [1] were synthesized. Single crystal structures and X-ray absorption spectroscopy measurements for these two model complexes are reported. In Zn(C6H12OS2)2(ClO 4)2, the Zn is coordinated by four sulfur and two oxygen atoms. The average ZnS bond length is 2.514 Å and the ZnO bond length is 2.089 Å, which are similar to these bond distances reported for the Zn site in the β′ subunit of RNA polymerase. In Zn(C3H6NS2)2(C3 H4N2), the Zn atom is coordinated by four sulfur atoms and one nitrogen atom of an imidazole group. The average of the ZnS bond length is 2.469 Å and the ZnN bond length is 2.009 Å, which are also similar to the ZnS and ZnN bonds in the β subunits of RNA polymerase.

AB - Model compounds for the Zn sites of the β′ and the β subunits in RNA polymerase [1] were synthesized. Single crystal structures and X-ray absorption spectroscopy measurements for these two model complexes are reported. In Zn(C6H12OS2)2(ClO 4)2, the Zn is coordinated by four sulfur and two oxygen atoms. The average ZnS bond length is 2.514 Å and the ZnO bond length is 2.089 Å, which are similar to these bond distances reported for the Zn site in the β′ subunit of RNA polymerase. In Zn(C3H6NS2)2(C3 H4N2), the Zn atom is coordinated by four sulfur atoms and one nitrogen atom of an imidazole group. The average of the ZnS bond length is 2.469 Å and the ZnN bond length is 2.009 Å, which are also similar to the ZnS and ZnN bonds in the β subunits of RNA polymerase.

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UR - https://www.scopus.com/pages/publications/0029030999#tab=citedBy

U2 - 10.1016/0162-0134(94)00058-I

DO - 10.1016/0162-0134(94)00058-I

M3 - Article

C2 - 7500087

AN - SCOPUS:0029030999

SN - 0162-0134

VL - 58

SP - 245

EP - 253

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 4

ER -

Synthesis and structures of Zn(C₆H₁₂OS₂)₂(ClO₄)₂ and Zn(C₃H₆NS₂)₂(C₃ H₄N₂)- Model compounds for the Zn sites in RNA polymerase

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