Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols

Carl E. Heltzel; A. A.Leslie Gunatilaka; David G.I. Kingston; Glenn A. Hofmann; Randall K. Johnson

doi:10.1021/np50107a009

Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols

Carl E. Heltzel
, A. A.Leslie Gunatilaka
, David G.I. Kingston
, Glenn A. Hofmann
, Randall K. Johnson

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The cytotoxic sterols 1 and 2, previously isolated from Pseudobersama mossambicenis, have been synthesized in nine steps from stigmasterol, together with seven related sterols. Structure-activity relationships of these sterols in cytotoxicity and DNA-damaging assays are discussed.

Original language	English (US)
Pages (from-to)	620-628
Number of pages	9
Journal	Journal Of Natural Products
Volume	57
Issue number	5
DOIs	https://doi.org/10.1021/np50107a009
State	Published - May 1 1994
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50107a009

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title = "Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols",

abstract = "The cytotoxic sterols 1 and 2, previously isolated from Pseudobersama mossambicenis, have been synthesized in nine steps from stigmasterol, together with seven related sterols. Structure-activity relationships of these sterols in cytotoxicity and DNA-damaging assays are discussed.",

author = "Heltzel, \{Carl E.\} and Gunatilaka, \{A. A.Leslie\} and Kingston, \{David G.I.\} and Hofmann, \{Glenn A.\} and Johnson, \{Randall K.\}",

year = "1994",

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doi = "10.1021/np50107a009",

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AU - Heltzel, Carl E.

AU - Gunatilaka, A. A.Leslie

AU - Kingston, David G.I.

AU - Hofmann, Glenn A.

AU - Johnson, Randall K.

PY - 1994/5/1

Y1 - 1994/5/1

N2 - The cytotoxic sterols 1 and 2, previously isolated from Pseudobersama mossambicenis, have been synthesized in nine steps from stigmasterol, together with seven related sterols. Structure-activity relationships of these sterols in cytotoxicity and DNA-damaging assays are discussed.

AB - The cytotoxic sterols 1 and 2, previously isolated from Pseudobersama mossambicenis, have been synthesized in nine steps from stigmasterol, together with seven related sterols. Structure-activity relationships of these sterols in cytotoxicity and DNA-damaging assays are discussed.

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UR - https://www.scopus.com/pages/publications/0028308393#tab=citedBy

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DO - 10.1021/np50107a009

M3 - Article

C2 - 8064294

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EP - 628

JO - Journal Of Natural Products

JF - Journal Of Natural Products

IS - 5

ER -

Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols

Abstract

ASJC Scopus subject areas

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