Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols

Carl E. Heltzel; A. A.Leslie Gunatilaka; David G.I. Kingston; Glenn A. Hofmann; Randall K. Johnson

doi:10.1021/np50107a009

Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols

Carl E. Heltzel, A. A.Leslie Gunatilaka, David G.I. Kingston, Glenn A. Hofmann, Randall K. Johnson

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The cytotoxic sterols 1 and 2, previously isolated from Pseudobersama mossambicenis, have been synthesized in nine steps from stigmasterol, together with seven related sterols. Structure-activity relationships of these sterols in cytotoxicity and DNA-damaging assays are discussed.

Original language	English (US)
Pages (from-to)	620-628
Number of pages	9
Journal	Journal Of Natural Products
Volume	57
Issue number	5
DOIs	https://doi.org/10.1021/np50107a009
State	Published - May 1 1994
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50107a009

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title = "Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols",

abstract = "The cytotoxic sterols 1 and 2, previously isolated from Pseudobersama mossambicenis, have been synthesized in nine steps from stigmasterol, together with seven related sterols. Structure-activity relationships of these sterols in cytotoxicity and DNA-damaging assays are discussed.",

author = "Heltzel, {Carl E.} and Gunatilaka, {A. A.Leslie} and Kingston, {David G.I.} and Hofmann, {Glenn A.} and Johnson, {Randall K.}",

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AU - Gunatilaka, A. A.Leslie

AU - Kingston, David G.I.

AU - Hofmann, Glenn A.

AU - Johnson, Randall K.

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AB - The cytotoxic sterols 1 and 2, previously isolated from Pseudobersama mossambicenis, have been synthesized in nine steps from stigmasterol, together with seven related sterols. Structure-activity relationships of these sterols in cytotoxicity and DNA-damaging assays are discussed.

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Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols

Abstract

ASJC Scopus subject areas

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