TY - GEN
T1 - Synthesis and characterization of copolymeric micelles loaded with Taxol® as potential drug delivery systems for cancer treatment
AU - Tapia, L. V.
AU - Castro, J. S.
AU - Martinez, C. A.
AU - Garcia, P. E.
AU - Rodriguez, C. A.
AU - Deymier, P. A.
PY - 2011
Y1 - 2011
N2 - Taxol (Paclitaxel) is a very potent anticancer drug used in chemotherapy treatments. Due to its hydrophobic nature, toxic solubilizing agents are used to administer the drug via intravenously. However, this systemic administration is associated with toxic side effects and drug limited efficacy. An alternative to these problems are polymeric micelles. The effectiveness of this drug delivery system is related to its size, modification of pharmacokinetics, drug delivery control and toxicity reduction. In this study, micelles based on methoxy Poly(ethylene glycol)-block-Poly(ε-caprolactone) (mPEG-b-PCL) copolymer loaded with Taxol were synthesized thorough an uncommon method namely powder formulation, using tert-butanol as co-solvent, to our knowledge no reported previously for these micells. Taxol was conjugated to the hydrophobic block of mPEG-b-PCL copolymer. Characterization of this system was done by means of Fourier Transform Infrared Spectroscopy (FT-IR) and Field Emission Scanning Electron Microscopy (FESEM), observing good results as compared to previous reports.
AB - Taxol (Paclitaxel) is a very potent anticancer drug used in chemotherapy treatments. Due to its hydrophobic nature, toxic solubilizing agents are used to administer the drug via intravenously. However, this systemic administration is associated with toxic side effects and drug limited efficacy. An alternative to these problems are polymeric micelles. The effectiveness of this drug delivery system is related to its size, modification of pharmacokinetics, drug delivery control and toxicity reduction. In this study, micelles based on methoxy Poly(ethylene glycol)-block-Poly(ε-caprolactone) (mPEG-b-PCL) copolymer loaded with Taxol were synthesized thorough an uncommon method namely powder formulation, using tert-butanol as co-solvent, to our knowledge no reported previously for these micells. Taxol was conjugated to the hydrophobic block of mPEG-b-PCL copolymer. Characterization of this system was done by means of Fourier Transform Infrared Spectroscopy (FT-IR) and Field Emission Scanning Electron Microscopy (FESEM), observing good results as compared to previous reports.
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U2 - 10.1557/opl.2012.283
DO - 10.1557/opl.2012.283
M3 - Conference contribution
AN - SCOPUS:84879232912
SN - 9781627482028
T3 - Materials Research Society Symposium Proceedings
SP - 67
EP - 72
BT - Biomaterials for Medical Applications
T2 - 20th International Materials Research Congress, IMRC 2011
Y2 - 14 August 2011 through 19 August 2011
ER -