Synthesis and biological evaluation on hMC₃, hMC₄ and hMC₅ receptors of γ-MSH analogs substituted with L-alanine

Keyphrases

• Melanocortin 1 Receptor (MC1R) 100%
• Biological Evaluation 100%
• Synthetic Evaluation 100%
• Melanocortin 4 Receptor (MC4R) 66%
• MC5R 66%
• MC3R 66%
• Amino Acids 33%
• Agonist Activity 33%
• Biological Activity 33%
• Binding Affinity 33%
• Binding Assay 33%
• Receptor Binding 33%
• His6 33%
• Cell-based Assay 33%
• C-terminal Region 33%
• Intracellular cAMP 33%
• Structure-activity Studies 33%
• Agonist Efficacy 33%
• Human Receptor 33%
• CHO Cells 33%
• Dodecapeptide 33%

Neuroscience

• Melanocyte-Stimulating Hormone 100%
• Alanine 100%
• Melanocortin Receptor 60%
• Arginine 40%
• Agonist 40%
• Binding Affinity 20%
• C-Terminus 20%
• Amino Acid 20%
• Cell Line 20%
• Cyclic Adenosine Monophosphate 20%
• Receptor Binding 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Intermedin 100%
• Alanine 100%
• Melanocortin Receptor 60%
• Arginine 40%
• Biological Activity 20%
• Receptor 20%
• Amino Acid 20%