Synthesis and biological evaluation of Nα-hydroxysulfonyl-[Nle28,31]-CCK26-33

Elizabeth E. Sugg; Jennifer E. Shook; Mariangela Serra; Murray Korc; Henry I. Yamamura; Thomas F. Burks; Victor J. Hruby

doi:10.1016/0024-3205(86)90158-X

Synthesis and biological evaluation of N^α-hydroxysulfonyl-[Nle^28,31]-CCK_26-33

Elizabeth E. Sugg, Jennifer E. Shook, Mariangela Serra, Murray Korc, Henry I. Yamamura, Thomas F. Burks, Victor J. Hruby

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Two analogues of [Nle^28,31]-CCK_26-33 containing an N-terminal acetyl or N-terminal hydroxysulfonyl moiety were prepared and characterized. Both analogues were equipotent to native CCK_26-33 in four bioassays, demonstrating that N-terminal sulfation of CCK_26-33 analogues is compatible with full biological activity.

Original language	English (US)
Pages (from-to)	1623-1629
Number of pages	7
Journal	Life Sciences
Volume	39
Issue number	18
DOIs	https://doi.org/10.1016/0024-3205(86)90158-X
State	Published - Nov 3 1986
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(86)90158-X

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@article{947b4c2de6c9492fba4949fd1f9de03b,

title = "Synthesis and biological evaluation of Nα-hydroxysulfonyl-[Nle28,31]-CCK26-33",

abstract = "Two analogues of [Nle28,31]-CCK26-33 containing an N-terminal acetyl or N-terminal hydroxysulfonyl moiety were prepared and characterized. Both analogues were equipotent to native CCK26-33 in four bioassays, demonstrating that N-terminal sulfation of CCK26-33 analogues is compatible with full biological activity.",

author = "Sugg, {Elizabeth E.} and Shook, {Jennifer E.} and Mariangela Serra and Murray Korc and Yamamura, {Henry I.} and Burks, {Thomas F.} and Hruby, {Victor J.}",

note = "Funding Information: This work was supported by U.S. Public Health 36289, HL 36042, MH 27257, and RSDA MHO0095.",

year = "1986",

month = nov,

day = "3",

doi = "10.1016/0024-3205(86)90158-X",

language = "English (US)",

volume = "39",

pages = "1623--1629",

journal = "Life Sciences",

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TY - JOUR

T1 - Synthesis and biological evaluation of Nα-hydroxysulfonyl-[Nle28,31]-CCK26-33

AU - Sugg, Elizabeth E.

AU - Shook, Jennifer E.

AU - Serra, Mariangela

AU - Korc, Murray

AU - Yamamura, Henry I.

AU - Burks, Thomas F.

AU - Hruby, Victor J.

N1 - Funding Information: This work was supported by U.S. Public Health 36289, HL 36042, MH 27257, and RSDA MHO0095.

PY - 1986/11/3

Y1 - 1986/11/3

N2 - Two analogues of [Nle28,31]-CCK26-33 containing an N-terminal acetyl or N-terminal hydroxysulfonyl moiety were prepared and characterized. Both analogues were equipotent to native CCK26-33 in four bioassays, demonstrating that N-terminal sulfation of CCK26-33 analogues is compatible with full biological activity.

AB - Two analogues of [Nle28,31]-CCK26-33 containing an N-terminal acetyl or N-terminal hydroxysulfonyl moiety were prepared and characterized. Both analogues were equipotent to native CCK26-33 in four bioassays, demonstrating that N-terminal sulfation of CCK26-33 analogues is compatible with full biological activity.

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U2 - 10.1016/0024-3205(86)90158-X

DO - 10.1016/0024-3205(86)90158-X

M3 - Article

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EP - 1629

JO - Life Sciences

JF - Life Sciences

IS - 18

ER -

Synthesis and biological evaluation of N^α-hydroxysulfonyl-[Nle^28,31]-CCK_26-33

Abstract

ASJC Scopus subject areas

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