Synthesis and biological evaluation of Nα-hydroxysulfonyl-[Nle28,31]-CCK26-33

Elizabeth E. Sugg, Jennifer E. Shook, Mariangela Serra, Murray Korc, Henry I. Yamamura, Thomas F. Burks, Victor J. Hruby

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Two analogues of [Nle28,31]-CCK26-33 containing an N-terminal acetyl or N-terminal hydroxysulfonyl moiety were prepared and characterized. Both analogues were equipotent to native CCK26-33 in four bioassays, demonstrating that N-terminal sulfation of CCK26-33 analogues is compatible with full biological activity.

Original languageEnglish (US)
Pages (from-to)1623-1629
Number of pages7
JournalLife Sciences
Issue number18
StatePublished - Nov 3 1986
Externally publishedYes

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology


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