Abstract
Analogs of the potent fecal mutagen fecapentaene-12 [1] have been prepared and tested both for mutagenicity and for their ability to serve as biological precursors of 1. It was found that mutagenicity in three different Salmonella tester strains TA96, TA100, and TA104, decreased rapidly as the number of conjugated double bonds was reduced. The aldehyde 8, analogous to the hydrolysis product of 1, showed only low mutagenicity, even in the aldehyde-sensitive strain TA104. None of the polyenes prepared was able to function as a direct biological precursor of of 1 under the conditions employed.
Original language | English (US) |
---|---|
Pages (from-to) | 75-83 |
Number of pages | 9 |
Journal | Journal Of Natural Products |
Volume | 50 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 1987 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry