Abstract
Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.
Original language | English (US) |
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Pages (from-to) | 2835-2838 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 43 |
Issue number | 15 |
DOIs | |
State | Published - Apr 8 2002 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry