Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

Haiying Sun; Gaddam Bapu Reddy; Clifford George; Emmanuelle J. Meuillet; Margareta Berggren; Garth Powis; Alan P. Kozikowski

doi:10.1016/S0040-4039(02)00354-4

Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

Haiying Sun, Gaddam Bapu Reddy, Clifford George, Emmanuelle J. Meuillet, Margareta Berggren, Garth Powis, Alan P. Kozikowski

Nutritional Sciences and Wellness, Research

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.

Original language	English (US)
Pages (from-to)	2835-2838
Number of pages	4
Journal	Tetrahedron Letters
Volume	43
Issue number	15
DOIs	https://doi.org/10.1016/S0040-4039(02)00354-4
State	Published - Apr 8 2002

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues. / Sun, Haiying; Bapu Reddy, Gaddam; George, Clifford; Meuillet, Emmanuelle J.; Berggren, Margareta; Powis, Garth; Kozikowski, Alan P.

In: Tetrahedron Letters, Vol. 43, No. 15, 08.04.2002, p. 2835-2838.

Research output: Contribution to journal › Article › peer-review

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abstract = "Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.",

author = "Haiying Sun and {Bapu Reddy}, Gaddam and Clifford George and Meuillet, {Emmanuelle J.} and Margareta Berggren and Garth Powis and Kozikowski, {Alan P.}",

note = "Funding Information: We thank the National Institutes of Health (Grant CA61015) for support of this research. ",

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AU - Sun, Haiying

AU - Bapu Reddy, Gaddam

AU - George, Clifford

AU - Meuillet, Emmanuelle J.

AU - Berggren, Margareta

AU - Powis, Garth

AU - Kozikowski, Alan P.

N1 - Funding Information: We thank the National Institutes of Health (Grant CA61015) for support of this research.

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AB - Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.

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Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

Abstract

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