Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

Haiying Sun; Gaddam Bapu Reddy; Clifford George; Emmanuelle J. Meuillet; Margareta Berggren; Garth Powis; Alan P. Kozikowski

doi:10.1016/S0040-4039(02)00354-4

Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

Haiying Sun, Gaddam Bapu Reddy, Clifford George, Emmanuelle J. Meuillet, Margareta Berggren, Garth Powis, Alan P. Kozikowski

Nutritional Sciences and Wellness, Research

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.

Original language	English (US)
Pages (from-to)	2835-2838
Number of pages	4
Journal	Tetrahedron Letters
Volume	43
Issue number	15
DOIs	https://doi.org/10.1016/S0040-4039(02)00354-4
State	Published - Apr 8 2002

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(02)00354-4

Cite this

@article{43ccd5e103de488b9099033e1fe53164,

title = "Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues",

abstract = "Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.",

author = "Haiying Sun and {Bapu Reddy}, Gaddam and Clifford George and Meuillet, {Emmanuelle J.} and Margareta Berggren and Garth Powis and Kozikowski, {Alan P.}",

note = "Funding Information: We thank the National Institutes of Health (Grant CA61015) for support of this research. ",

year = "2002",

month = apr,

day = "8",

doi = "10.1016/S0040-4039(02)00354-4",

language = "English (US)",

volume = "43",

pages = "2835--2838",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "15",

}

TY - JOUR

T1 - Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

AU - Sun, Haiying

AU - Bapu Reddy, Gaddam

AU - George, Clifford

AU - Meuillet, Emmanuelle J.

AU - Berggren, Margareta

AU - Powis, Garth

AU - Kozikowski, Alan P.

N1 - Funding Information: We thank the National Institutes of Health (Grant CA61015) for support of this research.

PY - 2002/4/8

Y1 - 2002/4/8

N2 - Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.

AB - Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.

UR - http://www.scopus.com/inward/record.url?scp=0037041364&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037041364&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(02)00354-4

DO - 10.1016/S0040-4039(02)00354-4

M3 - Article

AN - SCOPUS:0037041364

VL - 43

SP - 2835

EP - 2838

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 15

ER -

Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this