Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
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Sun, H. (Creator), Bapu Reddy, G. (Contributor), George, C. (Creator), Meuillet, E. J. (Creator), Berggren, M. (Creator), Powis, G. (Creator) & Kozikowski, A. P. (Creator), Cambridge Crystallographic Data Centre, 2002