Syntheses of optically pure, conformationally constrained, and highly hydrophobic unusual amino acids: 2-Amino-3, 3-diarylpropionic acids

J. Lin; S. Liao; V. J. Hruby

doi:10.1111/j.1399-3011.2004.00194.x

Syntheses of optically pure, conformationally constrained, and highly hydrophobic unusual amino acids: 2-Amino-3, 3-diarylpropionic acids

J. Lin
, S. Liao
, V. J. Hruby

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A series of optically pure, conformationally constrained, and highly hydrophobic unusual aromatic amino acids, 2-amino-3,3-diarylpropionic acids, were synthesized via asymmetric 1,4-Michael addition reaction/azidation reactions in seven steps with overall yields of 20-30%.

Original language	English (US)
Pages (from-to)	105-112
Number of pages	8
Journal	Journal of Peptide Research
Volume	65
Issue number	1
DOIs	https://doi.org/10.1111/j.1399-3011.2004.00194.x
State	Published - Jan 2005
Externally published	Yes

Keywords

Aromatic amino acids
Asymmetric synthesis
Conformationally constrained amino acids

ASJC Scopus subject areas

Biochemistry
Endocrinology

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10.1111/j.1399-3011.2004.00194.x

Cite this

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title = "Syntheses of optically pure, conformationally constrained, and highly hydrophobic unusual amino acids: 2-Amino-3, 3-diarylpropionic acids",

abstract = "A series of optically pure, conformationally constrained, and highly hydrophobic unusual aromatic amino acids, 2-amino-3,3-diarylpropionic acids, were synthesized via asymmetric 1,4-Michael addition reaction/azidation reactions in seven steps with overall yields of 20-30\%.",

keywords = "Aromatic amino acids, Asymmetric synthesis, Conformationally constrained amino acids",

author = "J. Lin and S. Liao and Hruby, \{V. J.\}",

year = "2005",

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AU - Liao, S.

AU - Hruby, V. J.

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KW - Aromatic amino acids

KW - Asymmetric synthesis

KW - Conformationally constrained amino acids

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Syntheses of optically pure, conformationally constrained, and highly hydrophobic unusual amino acids: 2-Amino-3, 3-diarylpropionic acids

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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