TY - JOUR
T1 - Synovitis in knee osteoarthritis
T2 - A precursor of disease?
AU - Atukorala, I.
AU - Kwoh, C. K.
AU - Guermazi, A.
AU - Roemer, F. W.
AU - Boudreau, R. M.
AU - Hannon, M. J.
AU - Hunter, D. J.
N1 - Funding Information:
The authors would like to thank the readers of the fixed flexion radiographs at Boston University for the central KL grading, the OAI investigators, clinic staff and OAI participants at each of the OAI clinical centres for their contributions in acquiring the publicly available clinical and imaging data, the team at the OAI coordinating centre, particularly John Lynch, Maurice Dockrell and Jason Maeda, for their help, and Stephanie Green and Hilary Peterson at Pittsburgh for administrative support. corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. The study and image acquisition was funded by the OAI, a public-private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners of the OAI include Merck Research Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and Pfizer. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health. The image analysis of this study was funded by a contract with the University of Pittsburgh (Pivotal OAI MRI Analyses POMA: NIH/NHLBI Contract No. HHSN2682010000 21C) and, in part, by a vendor contract from the OAI coordinating centre at University of California, San Francisco (N01-AR-2-2258). The statistical data analysis was funded by a contract with the University of Pittsburgh (Pivotal OAI MRI Analyses POMA: NIH/NHLBI Contract No. HHSN2682010000 21C) and the University of Pittsburgh Multidisciplinary Clinical Research Center (MCRC) for Rheumatic and Musculoskeletal Diseases (P60 AR054731). None of the study sponsors had any role in data collection, storage or analysis, in manuscript writing or the decision to publish this manuscript. AG is President and co-owner of the Boston Core Imaging Lab (BICL), a company providing MRI reading services to academic researchers and to industry. He has provided consulting services to Novartis, Merck Serono, Sanofi-Aventis, TissueGene and Genzyme. FWR is CMO and co-owner of the Boston Core Imaging Lab (BICL), a company providing MRI reading services to academic researchers and to industry. He has provided consulting services to Merck Serono. CKK has provided consulting services to Novartis and has received research support from Astra-Zeneca.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Objectives: It is unknown whether joint inflammation precedes other articular tissue damage in osteoarthritis. Therefore, this study aims to determine if synovitis precedes the development of radiographic knee osteoarthritis (ROA). Methods: The participants in this nested case-control study were selected from persons in the Osteoarthritis Initiative with knees that had a Kellgren Lawrence grading (KLG)=0 at baseline (BL). These knees were evaluated annually with radiography and non-contrastenhanced MRI over 4 years. MRIs were assessed for effusion-synovitis and Hoffa-synovitis. Case knees were defined by ROA (KLG≥2) on the postero-anterior knee radiographs at any assessment after BL. Radiographs were assessed at P0 (time of onset of ROA), 1 year prior to P0 (P-1) and at BL. Controls were participants who did not develop incident ROA (iROA) from BL to 48 months). Results: 133 knees of 120 persons with ROA (83 women) were matched to 133 control knees (83 women). ORs for occurrence of iROA associated with the presence of effusion-synovitis at BL, P-1 and P0 were 1.56 (95% CI 0.86 to 2.81), 3.23 (1.72 to 6.06) and 4.7 (1.10 to 2.95), respectively. The ORs for the occurrence of iROA associated with the presence of Hoffa-synovitis at BL, P-1 and P0 were 1.80 (1.1 to 2.95), 2.47 (1.45 to 4.23) and 2.40 (1.43 to 4.04), respectively. Conclusions: Effusion-synovitis and Hoffa-synovitis strongly predicted the development of iROA.
AB - Objectives: It is unknown whether joint inflammation precedes other articular tissue damage in osteoarthritis. Therefore, this study aims to determine if synovitis precedes the development of radiographic knee osteoarthritis (ROA). Methods: The participants in this nested case-control study were selected from persons in the Osteoarthritis Initiative with knees that had a Kellgren Lawrence grading (KLG)=0 at baseline (BL). These knees were evaluated annually with radiography and non-contrastenhanced MRI over 4 years. MRIs were assessed for effusion-synovitis and Hoffa-synovitis. Case knees were defined by ROA (KLG≥2) on the postero-anterior knee radiographs at any assessment after BL. Radiographs were assessed at P0 (time of onset of ROA), 1 year prior to P0 (P-1) and at BL. Controls were participants who did not develop incident ROA (iROA) from BL to 48 months). Results: 133 knees of 120 persons with ROA (83 women) were matched to 133 control knees (83 women). ORs for occurrence of iROA associated with the presence of effusion-synovitis at BL, P-1 and P0 were 1.56 (95% CI 0.86 to 2.81), 3.23 (1.72 to 6.06) and 4.7 (1.10 to 2.95), respectively. The ORs for the occurrence of iROA associated with the presence of Hoffa-synovitis at BL, P-1 and P0 were 1.80 (1.1 to 2.95), 2.47 (1.45 to 4.23) and 2.40 (1.43 to 4.04), respectively. Conclusions: Effusion-synovitis and Hoffa-synovitis strongly predicted the development of iROA.
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U2 - 10.1136/annrheumdis-2014-205894
DO - 10.1136/annrheumdis-2014-205894
M3 - Article
C2 - 25488799
AN - SCOPUS:84954361829
SN - 0003-4967
VL - 75
SP - 390
EP - 395
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 2
ER -