Synergistic interaction of the cannabinoid and death receptor systems – a potential target for future cancer therapies?

Attila Keresztes, John M. Streicher

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Cannabinoid receptors have been shown to interact with other receptors, including tumor necrosis factor receptor superfamily (TNFRS) members, to induce cancer cell death. When cannabinoids and death-inducing ligands (including TNF-related apoptosis-inducing ligand) are administered together, they have been shown to synergize and demonstrate enhanced antitumor activity in vitro. Certain cannabinoid ligands have been shown to sensitize cancer cells and synergistically interact with members of the TNFRS, thus suggesting that the combination of cannabinoids with death receptor (DR) ligands induces additive or synergistic tumor cell death. This review summarizes recent findings on the interaction of the cannabinoid and DR systems and suggests possible clinical co-application of cannabinoids and DR ligands in the treatment of various malignancies.

Original languageEnglish (US)
Pages (from-to)3235-3251
Number of pages17
JournalFEBS Letters
Volume591
Issue number20
DOIs
StatePublished - Oct 2017
Externally publishedYes

Keywords

  • apoptosis
  • cancer
  • cannabinoid
  • combination therapy
  • death receptor
  • TNF-related apoptosis-inducing ligand

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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