Synergistic chiral iminium and palladium catalysis: Highly regio- and enantioselective [3 + 2] annulation reaction of 2-vinylcyclopropanes with enals

Haipan Zhu, Peile Du, Jianjun Li, Ziyang Liao, Guohua Liu, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A cooperative catalytic strategy of chiral iminium catalysis by regioselective activation of the C=C bond in enals and a transition metal promoting to open the 2-vinylcyclopropanes for highly regio- and enantioselective [3 + 2] cycloaddition reaction of 2-vinylcyclopropanes with α,β-unsaturated aldehydes has been developed.

Original languageEnglish (US)
Pages (from-to)1340-1347
Number of pages8
JournalBeilstein Journal of Organic Chemistry
Volume12
DOIs
StatePublished - Jun 29 2016
Externally publishedYes

Keywords

  • Annulation
  • Enals
  • Synergistic catalysis
  • Vinylcyclopropanes

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Synergistic chiral iminium and palladium catalysis: Highly regio- and enantioselective [3 + 2] annulation reaction of 2-vinylcyclopropanes with enals'. Together they form a unique fingerprint.

Cite this