Synergetic roles of TGF-β signaling in tissue engineering

Eun A. Kwak; Nam Y. Lee

doi:10.1016/j.cyto.2018.12.010

Synergetic roles of TGF-β signaling in tissue engineering

Eun A. Kwak, Nam Y. Lee

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Recent advances in tissue engineering highlight biomaterial designs with context-specific growth factors, cytokines and various small molecules to better mimic the natural extracellular matrix (ECM) microenvironments. These efforts have led to direct improvements in cell-cell and cell-ECM interactions while mitigating undesirable cellular and immunogenic responses. In this short review, we focus on the crucial roles and regulation of transforming growth factor β (TGF-β) signaling in biomaterial applications during tissue repair and regeneration.

Original language	English (US)
Pages (from-to)	60-63
Number of pages	4
Journal	Cytokine
Volume	115
DOIs	https://doi.org/10.1016/j.cyto.2018.12.010
State	Published - Mar 2019

Keywords

Biomaterials
Inflammation
Regenerative medicine
TGF beta
Tissue engineering

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Molecular Biology
Hematology

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10.1016/j.cyto.2018.12.010

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title = "Synergetic roles of TGF-β signaling in tissue engineering",

abstract = "Recent advances in tissue engineering highlight biomaterial designs with context-specific growth factors, cytokines and various small molecules to better mimic the natural extracellular matrix (ECM) microenvironments. These efforts have led to direct improvements in cell-cell and cell-ECM interactions while mitigating undesirable cellular and immunogenic responses. In this short review, we focus on the crucial roles and regulation of transforming growth factor β (TGF-β) signaling in biomaterial applications during tissue repair and regeneration.",

keywords = "Biomaterials, Inflammation, Regenerative medicine, TGF beta, Tissue engineering",

author = "Kwak, {Eun A.} and Lee, {Nam Y.}",

note = "Funding Information: This work was supported in part by NIH CA178443 awarded to N.Y.L., and University of Arizona Cancer Center and University of Arizona Department of Pharmacology and Department of Chemistry and Biochemistry for internal funding. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

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AU - Lee, Nam Y.

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N2 - Recent advances in tissue engineering highlight biomaterial designs with context-specific growth factors, cytokines and various small molecules to better mimic the natural extracellular matrix (ECM) microenvironments. These efforts have led to direct improvements in cell-cell and cell-ECM interactions while mitigating undesirable cellular and immunogenic responses. In this short review, we focus on the crucial roles and regulation of transforming growth factor β (TGF-β) signaling in biomaterial applications during tissue repair and regeneration.

AB - Recent advances in tissue engineering highlight biomaterial designs with context-specific growth factors, cytokines and various small molecules to better mimic the natural extracellular matrix (ECM) microenvironments. These efforts have led to direct improvements in cell-cell and cell-ECM interactions while mitigating undesirable cellular and immunogenic responses. In this short review, we focus on the crucial roles and regulation of transforming growth factor β (TGF-β) signaling in biomaterial applications during tissue repair and regeneration.

KW - Biomaterials

KW - Inflammation

KW - Regenerative medicine

KW - TGF beta

KW - Tissue engineering

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Synergetic roles of TGF-β signaling in tissue engineering

Abstract

Keywords

ASJC Scopus subject areas

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